Abstract
To study the efficacy and safety of cereton in the treatment of patients with chronic brain ischemia and moderate cognitive impairment. The study included 25 patients, 16 women and 9 men, mean age 53,8 ± 1,3 years. Moderate cognitive impairment measured with MMSE and HADS was found in all patients. Quality of life was assessed with SF-36. Somatic and neurological studies as well as brain MRI were carried out. Inpatients received cereton in dose 1000 mg in 200 ml of physiological solution during 15 days, after the discharge from the hospital patients received 1 capsule three times a day during 3 months. RESULTS AND СONCLUSION: Cereton had a significant positive effect on patient's condition including cognitive function. Subjective effect was recorded after 5-6 days of treatment, more evident and stable effect was seen from the 15th day. In the end of treatment, clinicians recorded "moderate" effect in 11 patients and "marked" effect in 8 patients (according to patients' reports, those effects were noted in 9 and 12 cases, respectively). The drug was well-tolerated and had a positive effect on quality of life of the patients.
References
Apr 6, 1999·Archives of Neurology·R C PetersenE Kokmen
Oct 9, 2001·Mechanisms of Ageing and Development·L ParnettiV Gallai
Dec 26, 2001·Archives of Neurology·R C PetersenB Winblad
Jan 10, 2002·Stroke; a Journal of Cerebral Circulation·Robertus H C BisschopsJeroen van der Grond
Feb 27, 2003·Acta Neurologica Scandinavica. Supplementum·Vesna Jelic, Bengt Winblad
Mar 8, 2003·Stroke; a Journal of Cerebral Circulation·D R RutgersJ van der Grond
Mar 15, 2003·Clinical Therapeutics·Maria De Jesus Moreno Moreno
Jul 10, 2003·Lancet Neurology·John T O'BrienSteven T DeKosky
Oct 13, 2004·Neurology·W L XuL Fratiglioni
Nov 13, 2004·Journal of the Neurological Sciences·Timo ErkinjunttiSerge Gauthier
Aug 6, 2005·BMJ : British Medical Journal·Hanna KaduszkiewiczHendrik van den Bussche
Oct 7, 2005·The New England Journal of Medicine·Alberto J L Macario, Everly Conway de Macario
Jul 12, 2008·Stroke; a Journal of Cerebral Circulation·Susana Muñoz ManiegaJoanna M Wardlaw
Mar 24, 2009·Journal of the Neurological Sciences·Seyed Khosrow TayebatiFrancesco Amenta
Jan 5, 2011·Journal of the Neurological Sciences·Seyed Khosrow TayebatiFrancesco Amenta
Sep 17, 2013·Revue neurologique·S Debette
Citations
Jan 17, 2017·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·M V Putilina
Jun 5, 2018·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·I A GaponenkoA S Rozhdestvenskiy
Oct 26, 2021·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·Yu D MininaO V Androfagina