Abstract
Clonidine is an alpha-2 agonist traditionally used as an antihypertensive, and more recently in the treatment of psychiatric disorders such as attention-deficit hyperactive disorder (ADHD), tic disorders such as Tourette's syndrome, and post-traumatic stress disorder (PTSD). However, there are scarce data in the literature about the use of clonidine in the treatment of obsessive-compulsive disorder (OCD). In this report, we present the case of a 16-year-old female suffering from OCD. The first-line treatment with sertraline was not very efficacious in improving her symptoms and even led to worsening of the same. However, subsequent treatment with clonidine resulted in rapid and significant improvement in her condition. We postulate that further research is required to gain more insight into the therapeutic potential of clonidine in OCD patients.
References
May 1, 1991·Psychiatry Research·E HollanderM R Liebowitz
May 15, 1990·Biological Psychiatry·M A LeeG C Curtis
Aug 1, 1988·The American Journal of Psychiatry·E HollanderM R Liebowitz
Mar 1, 1988·Neurology·E D CaineJ Shiao
Feb 1, 1983·The British Journal of Psychiatry : the Journal of Mental Science·L J SieverD L Murphy
Feb 28, 1996·Psychiatry Research·T P ZahnJ L Rapoport
Mar 24, 1997·Psychiatry Research·F BrambillaF Gava
Mar 24, 1997·Psychiatry Research·F BrambillaF Gava
Jan 7, 2004·Journal of Affective Disorders·B R SlaapJ A den Boer
Mar 29, 2006·The Journal of Clinical Psychiatry·Helen Blair SimpsonMichael R Liebowitz
Dec 20, 2015·Progress in Neuro-psychopharmacology & Biological Psychiatry·Murad Atmaca
May 11, 2016·Pharmacology·Ahmed Naguy
Jun 1, 2018·Continuum : Lifelong Learning in Neurology·Peggy M A Richter, Renato T Ramos
Oct 3, 2018·Neuroscience and Biobehavioral Reviews·Lisa KloftNorbert Kathmann
Apr 5, 2019·Neuron·Trevor W RobbinsPaula Banca
Apr 10, 2019·Current Neuropharmacology·Chiara RapinesiAntonio Del Casale
Apr 25, 2019·Current Psychiatry Reports·Brittany M MathesNorman B Schmidt
Aug 3, 2019·Nature Reviews. Disease Primers·Dan J SteinH Blair Simpson
Nov 25, 2019·Psychiatria polska·Waldemar KrzyszkowiakEliza Krzanowska