The use of conization to identify and treat severe lesions among prediagnosed CIN1 and 2 patients in Japan

Journal of Gynecologic Oncology
Mikio MikamiHidetaka Katabuchi

Abstract

To evaluate the clinical efficiency of identifying patients with suspicious severe lesions by conization among prediagnosed cervical intraepithelial neoplasia (CIN) 1 and 2 patients in Japan. The data in a Japanese nation-wide registry for cervical cancer (2009 and 2011) was collected to analyze the clinical efficacy of pre- and postdiagnosis for 13,215 Japanese women who underwent treatment by conization. Their preoperative and postoperative histologic findings and clinical outcomes were evaluated using standard statistical procedures including clinical and demographic characteristics. Almost half of 1,536 women who were treated by conization after the prediagnosis of CIN1 and 2 because the lesions showed no evidence of natural regression actually contained CIN1-2 (45.0%), CIN3 (47%), or invasive cancer (2.7%) in their cervical tissue. They underwent conization either for therapeutic (treatment) (78.5%) or diagnostic (21.5%) reasons. Invasive disease was diagnosed postoperatively more often in diagnostic cases (6.1%) than in therapeutic cases (2.8%). All the patients survived their diagnostic and therapeutic conization after approximately 30 months of follow up. Our study shows that the continuous observation of the prediagnos...Continue Reading

References

May 15, 1976·American Journal of Obstetrics and Gynecology·B BjerreN O Sjöberg
May 1, 1986·Obstetrics and Gynecology·K NasiellM Nasiell
Feb 26, 1999·Journal of the National Cancer Institute·P HolowatyT To
Mar 5, 2004·British Journal of Cancer·C ScheungraberA Schneider
Sep 10, 2005·Best Practice & Research. Clinical Obstetrics & Gynaecology·B G Lindeque
Nov 8, 2005·Gynecologic Oncology·Masatsugu UedaMinoru Ueki
May 5, 2012·Indian Journal of Medical and Paediatric Oncology : Official Journal of Indian Society of Medical & Paediatric Oncology·Gauravi A MishraSurendra S Shastri
Mar 25, 2015·International Journal of Clinical Oncology·Yasuhiko EbinaHiroyuki Yoshikawa
Dec 9, 2015·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Nancy SantessoHolger J Schünemann
Dec 15, 2015·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Mert Ulaş BarutTalip Gül
Oct 18, 2016·Journal of Lower Genital Tract Disease·Anna J Koné PéfoyoRachel Kupets
Dec 21, 2016·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Yuri SasakiRyo Konno
Jan 7, 2017·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·James S Lewis
Feb 16, 2017·Journal of Gynecologic Oncology·Wataru YamagamiHidetaka Katabuchi
May 10, 2017·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Federica TomaoFabio Landoni
Jul 12, 2017·Acta Cytologica·Ritu Nayar, David C Wilbur

❮ Previous
Next ❯

Citations

Oct 3, 2019·The Journal of Obstetrics and Gynaecology Research·Rumiko YamamotoHidetaka Katabuchi

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
biopsies

Software Mentioned

Statistical Package for Social Sciences

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.