The Use of Continuous Blood Purification for the Treatment of Malignant Hyperthermia in an Infant.

Journal of Cardiothoracic and Vascular Anesthesia
Chuqiao ShengYumei Li

Abstract

Malignant hyperthermia (MH) is a rare and potentially life-threatening pharmacogenetic disorder encountered during general anesthesia, with the incidence higher in children than in adults. Dantrolene is the specific antagonist of MH, but it is not readily available in China, thus developing alternative treatment protocols is of great practical importance. Herein, the authors report a two-month-old infant who underwent holmium laser epiglottis retrofitting through a bronchoscope, but developed limb muscular stiffness, tachypnea, tachycardia, and hyperthermia after sevoflurane exposure. After the diagnosis of MH, corresponding supportive treatment was implemented. Because there was no dantrolene available, continuous blood purification and mechanical ventilation were performed. A few days later, the boy recovered without any complications. Based on the authors' successful clinical practice, the authors consider continuous blood purification as a reliable treatment for MH. But its feasibility still needs to be clarified after multicenter clinical observations.

References

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Jun 1, 2011·British Journal of Anaesthesia·P M Hopkins
Mar 20, 2013·BioMed Research International·R A Bannister
Jul 19, 2015·British Journal of Anaesthesia·P M HopkinsUNKNOWN European Malignant Hyperthermia Group
Aug 5, 2015·Orphanet Journal of Rare Diseases·Henry RosenbergKathryn Stowell
Apr 5, 2017·Proceedings of the National Academy of Sciences of the United States of America·Rocky H ChoiBradley S Launikonis
Sep 14, 2017·Anesthesiology·Ronald S LitmanSheila Riazi
Sep 14, 2017·Anesthesiology·Sheila RiaziPhilip M Hopkins
Sep 20, 2017·Anesthesiology·Marilyn Green Larach
Dec 19, 2019·Journal of Cardiothoracic and Vascular Anesthesia·Thomas PhillipsValerie Sera
Feb 6, 2020·Anesthesiology Clinics·Herodotos Ellinas, Meredith A Albrecht
Aug 31, 2020·British Journal of Anaesthesia·Carlos A Ibarra MorenoSheila Riazi

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