PMID: 16637477Apr 28, 2006Paper

The use of COX-2 inhibitors for acute dental pain: A second look

The Journal of the American Dental Association
Michaell A Huber, Geza T Terezhalmy

Abstract

On the basis of their perceived better safety profile compared with other analgesic agents, cyclo-oxygenase-2 (COX-2) inhibitors have been prescribed frequently as first-line agents to treat acute dental pain. However, recently identified cardiovascular adverse reactions associated with these drugs mandate a reappraisal of their use in dental practice. TYPES OF STUDIES REVIEWED. The authors reviewed 18 clinical studies that evaluated the efficacy of a COX-2 inhibitor for the treatment of acute dental pain. All of the studies used the widely established third-molar surgical extraction model to induce postsurgical inflammatory based pain, and all were randomized, double-blinded and placebo-controlled. However, numerous vagaries in overall study design made direct comparisons difficult. None of the studies established any of the COX-2 inhibitors as clearly better than ibuprofen, the current gold standard for the treatment of surgically induced dental pain. However, in single-dosing scenarios, the COX-2 inhibitor often demonstrated a longer duration of action compared with ibuprofen. The evidence to date fails to demonstrate any therapeutic advantage to using a COX-2 inhibitor to treat acute dental pain compared with ibuprofen. In ...Continue Reading

Citations

Dec 2, 2009·Inflammopharmacology·K D Rainsford
Jun 3, 2011·Clinical and Experimental Pharmacology & Physiology·Megan M WennerWilliam B Farquhar
Aug 21, 2012·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Francisco Javier Herrera-BrionesManuel Vallecillo Capilla

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