PMID: 7529131Jan 15, 1995Paper

The use of digital image analysis of chromatin texture in Feulgen-stained nuclei to predict recurrence of low grade superficial transitional cell carcinoma of the bladder

Cancer
R van VelthovenR Kiss

Abstract

Identifying a marker enabling prediction of recurrence in the group of superficial transitional cell carcinomas (sTCCs) of the bladder remains an important challenge today. This report quantitatively describes chromatin patterns with respect to such sTCC recurrence. Twenty-nine patients with sTCCs who did not exhibit tumor recurrence within a minimum of 24 months were compared with 21 patients with sTCCs who exhibited tumor recurrence two or three times in a 24-month period, for a total of 74 sTCCs. Quantitative chromatin pattern description was performed by the digital cell image analyses of Feulgen-stained nuclei. Six morphonuclear parameters were thus described and subsequently used to determine a score, allowing biological behavior of sTCCs to be described, i.e., recurrence versus non-recurrence in one calculation step. DNA ploidy level was also determined in each sTCC by assessing its DNA histogram type. Of 32 patients with Grade 1 pathologically classified pTa/pT1 tumors, DNA ploidy level determination permitted correct prediction of tumor nonrecurrence or recurrence of 13 (41%), whereas determination of the score values enabled prediction of nonrecurrence or recurrence of 25 (78%). Combining DNA ploidy level data and the...Continue Reading

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Citations

Nov 29, 2007·Journal of Cellular Biochemistry·Lawrence D True, C Diana Jordan
Aug 23, 2006·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Nor F RajabValerie J McKelvey-Martin
Nov 7, 2009·Diagnostic Cytopathology·Pranab Dey
May 1, 1996·Human Pathology·L D True
Mar 12, 2015·Journal of Tissue Engineering and Regenerative Medicine·Joana LoboAbhay Pandit

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