PMID: 9657278Jul 10, 1998Paper

The use of dogs as second species in regulatory testing of pesticides. I. Interspecies comparison

Archives of Toxicology
U Gerbracht, Horst Spielmann

Abstract

The relevance of studies in dogs on regulatory testing of pesticides was examined retrospectively using data of 216 pesticides (acaricides, fungicides, growth regulators and hormones, herbicides, insecticides, molluscicides, nematicides, rodenticides, synergists for insecticides) submitted for regulatory purposes during the past 40 years to the Federal Institute of Health Protection of Consumers and Veterinary Medicine (BgVV), the competent national authority in Germany. At first the relevance of the no-observed-effect levels (NOEL) for safety assessment was evaluated for each chemical in 4-week (subacute), 13-week (subchronic) and 52/104-week (chronic) toxicity studies carried out on dogs, rats and mice. After subchronic and chronic application of fungicides the sensitivity of rats and dogs to the toxic chemicals was quite similar. However, the dog was generally a more sensitive species to toxic effects of insecticides than rat and mouse. On the other hand the NOEL was lower in the rat than the dog in chronic studies on herbicides. When the lowest-observed-effect level (LOEL) was evaluated in animal species, the dog was the most sensitive in approximately 15% of the studies. Mice were found to be the most sensitive species onl...Continue Reading

Citations

Dec 16, 1998·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·N J Swales, D Utesch
Apr 22, 2010·Regulatory Toxicology and Pharmacology : RTP·Jürg A ZarnJosef R Schlatter
Mar 11, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·UNKNOWN EFSA GMO Panel Working Group on Animal Feeding Trials
May 12, 2004·Regulatory Toxicology and Pharmacology : RTP·K SchneiderM Hassauer
Dec 20, 2011·Regulatory Toxicology and Pharmacology : RTP·Peter J BoogaardGary D Minsavage
Mar 23, 2017·Critical Reviews in Toxicology·Brenda LinkeYadvinder Bhuller
May 1, 2000·Alternatives to Laboratory Animals : ATLA·U G SauerR Kolar
Aug 17, 2001·Alternatives to Laboratory Animals : ATLA·C L Broadhead, R D Combes

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