PMID: 9440308Jan 24, 1998Paper

The use of endogenous antioxidants to improve photoprotection

Journal of Photochemistry and Photobiology. B, Biology
D P Steenvoorden, G M van Henegouwen

Abstract

The skin possesses an elaborate antioxidant defence system to deal with UV-induced oxidative stress. However, excessive exposure to UV can overwhelm the cutaneous antioxidant capacity, leading to oxidative damage and ultimately to skin cancer, immunosuppression and premature skin aging. Therefore, an interesting strategy for photoprotection is the support of the endogenous antioxidant system. This can be accomplished by induction or transdermal delivery of the various antioxidant enzymes, such as glutathione peroxidase, catalase, or superoxide dismutase. Supplementation of non-enzymatic antioxidants such as glutathione, alpha-tocopherol, ascorbate and beta-carotene was also found to be very effective in photoprotection. Although treatments with single components of the antioxidant system were successful against a wide variety of photodamage, the balance between the different antioxidants in the skin is very important. In some studies, it was found that too much of a single component could even have deleterious effects. The most promising results were obtained in studies combining several compounds, often resulting in synergism of the protective effects.

References

Nov 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·M R ChedekelD L Vessell
Mar 1, 1978·The Journal of Investigative Dermatology·G De RiosJ M Knox
Sep 1, 1992·The British Journal of Dermatology·D DarrS Pinnell
Jun 24, 1991·FEBS Letters·D Njus, P M Kelley
Jul 30, 1991·Biochimica Et Biophysica Acta·P MorlièreL Dubertret
Dec 1, 1991·The American Journal of Clinical Nutrition·E Niki
Jan 1, 1990·Archives of Dermatological Research·C SundaramK U Schallreuter
Jan 1, 1990·Annual Review of Nutrition·G W Burton, M G Traber
Jun 1, 1987·Journal of Pharmacobio-dynamics·Y MiyachiY Niwa
Dec 1, 1989·The Journal of Investigative Dermatology·J FuchsL Packer
Jan 1, 1989·Free Radical Biology & Medicine·K U Schallreuter, J M Wood
Jan 1, 1985·Annual Review of Nutrition·P B McCay
Feb 1, 1987·Photochemistry and Photobiology·W KorytowskiB Kalyanaraman
Jun 3, 1988·Science·J A Imlay, S Linn
Aug 1, 1987·Photochemistry and Photobiology·M J Connor, L A Wheeler
Dec 10, 1986·Biochimica Et Biophysica Acta·J P ThomasA W Girotti
Jun 1, 1985·Archives of Biochemistry and Biophysics·M E AndersonA Meister
Jul 1, 1985·Photochemistry and Photobiology·M M Mathews-Roth, N I Krinsky
Mar 11, 1968·Archives of Biochemistry and Biophysics·M A Pathak, K Stratton
Oct 1, 1972·The Journal of Investigative Dermatology·M M Mathews-RothW Clemens

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Citations

Jul 23, 1999·BioFactors·U HoppeF Steckel
Jun 2, 2005·Journal of the American Academy of Dermatology·Prisana Kullavanijaya, Henry W Lim
Dec 22, 1999·Seminars in Cutaneous Medicine and Surgery·C F Rosen
Jul 7, 1999·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·R Kohen
Oct 31, 2001·Nutrition·S S Shapiro, C Saliou
Nov 24, 1999·International Journal of Dermatology·A F AlexisM J Stiller
Aug 23, 2006·The British Journal of Nutrition·Myriam RichelleGary Williamson
Nov 29, 2011·Photochemistry and Photobiology·Sreekanth NarayanapillaiRajesh Agarwal
Jan 18, 2006·Journal of Biomedical Optics·Igor V ErmakovW Gellermann
Sep 2, 2010·PloS One·Aniruddha SenguptaDolph L Hatfield
Oct 17, 2012·Clinical, Cosmetic and Investigational Dermatology·Daniela BuonocoreFulvio Marzatico
Dec 11, 2002·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Tracy L BialyJane M Grant-Kels
Feb 24, 2001·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·S R PinnellM Levine
Apr 3, 2013·Toxicology and Applied Pharmacology·Yuanqin YinZhuo Zhang
Jan 16, 2016·Journal of Biochemical and Molecular Toxicology·Balakrishnan AristatileKodukkur Viswanathan Pugalendi
Sep 20, 2011·Journal of Photochemistry and Photobiology. B, Biology·Adriana FilipI D Postescu
Jun 15, 2011·Journal of the American Academy of Dermatology·Maryam M AsgariEmily White
Mar 2, 2010·Journal of the American Academy of Dermatology·Jamie ZussmanJenny Kim
Jan 27, 2009·Clinics in Dermatology·Richard L RobertsBrandon Lewis
Mar 11, 2004·The Journal of Investigative Dermatology·Erica H LeeRichard D Granstein
Jan 19, 2006·The Journal of Investigative Dermatology·Vittoria MarescaMauro Picardo
Mar 5, 2002·The Journal of Investigative Dermatology·Olivier SorgJean-Hilaire Saurat
Jan 2, 2007·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Valéria Maria Di Mambro, Maria José Vieira Fonseca
May 1, 2004·International Journal of Dermatology·Christina S SanderJens J Thiele
Dec 14, 2006·Journal of Cosmetic Dermatology·M Andreassi, L Andreassi
Jul 1, 2005·Environmental Toxicology and Pharmacology·Nagarajan Rajendra PrasadKodukkur Viswanathan Pugalendi
Sep 4, 2004·Comptes rendus biologies·Olivier Sorg
Jan 31, 2006·Archives of Gerontology and Geriatrics·Jaime MiquelJoaquin Diaz Alperi
Aug 22, 2000·The Journal of Investigative Dermatology·T R HataL K Pershing
Jul 26, 2011·Journal of Biomedicine & Biotechnology·Barbara IovineMaria Assunta Bevilacqua

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