The use of estradiol for luteal phase support in in vitro fertilization/intracytoplasmic sperm injection cycles: a systematic review and meta-analysis

Fertility and Sterility
Tarek A GelbayaLuciano G Nardo

Abstract

To investigate the effect of luteal E(2) supplementation on the pregnancy rate of IVF/intracytoplasmic sperm injection (ICSI) cycles. A systematic review and meta-analysis of all the randomized controlled trials (RCTs). Tertiary referral center for reproductive medicine and IVF. Women undergoing IVF or ICSI using the GnRH agonist or GnRH antagonist protocol with hMG or FSH for controlled ovarian hyperstimulation. Progesterone (P4) alone or combined with estradiol valerate for luteal phase support. Pregnancy and clinical pregnancy rates per ET. An electronic search was conducted targeting all reports published between January 1960 and March 2007. Ten RCTs met the criteria for inclusion in the meta-analysis. There were no statistically significant differences with regard to the main outcome measures, ongoing pregnancy rate per ET, or implantation rate between the group of women who had combined E(2) and P4 therapy and those who had P4 supplementation alone. The addition of E(2) to P4 for luteal phase support in IVF/ICSI cycles has no beneficial effect on pregnancy rates. The data in the literature are, however, limited and heterogeneous, precluding the extraction of clear and definite conclusions. A large multicenter, properly de...Continue Reading

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Citations

Jul 2, 2011·Journal of Assisted Reproduction and Genetics·Marzieh AghahosseiniMaryam Khodaverdi
Mar 1, 2012·Reproductive Biology and Endocrinology : RB&E·Paul R BrezinaYulian Zhao
Mar 31, 2009·Human Fertility : Journal of the British Fertility Society·Luciano G NardoUNKNOWN Policy & Practice Committee of the British Fertility Society
Nov 26, 2011·Reproductive Biomedicine Online·Mikael Tang-PedersenAnne Lis Mikkelsen
Jan 5, 2013·European Journal of Obstetrics, Gynecology, and Reproductive Biology·H LinD Yang
Feb 14, 2015·Reproductive Biomedicine Online·C MotteramL J Rombauts
Jul 21, 2016·Human Fertility : Journal of the British Fertility Society·Wael A Ismail MadkourAshraf Moawad
Jan 30, 2019·Human Fertility : Journal of the British Fertility Society·Isıl KasapogluGürkan Uncu
Aug 4, 2020·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Konstantsa NeykovaGeorgi Vakrilov

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