The use of gallium-67 scintigraphy in the diagnosis of acute interstitial nephritis

Clinical Kidney Journal
François GrahamGuillaume Bollée

Abstract

Gallium-67 scintigraphy has been suggested as a noninvasive method to diagnose acute interstitial nephritis (AIN). However, its diagnostic performance and usefulness remain controversial. We retrospectively reviewed the charts of 76 patients who underwent gallium-67 scintigraphy for a suspicion of AIN. Patients were classified based on kidney biopsy and/or clinical probability of AIN. Gallium-67 scintigraphy results were reinterpreted blindly using both posterior planar and single photon emission computed tomography (SPECT) imaging. Intensity of radioisotope uptake in the kidney was graded from 0 to 5. The diagnosis of AIN was confirmed in 23 patients and excluded in 44. Nine patients with an uncertain diagnosis were excluded from subsequent analysis. A gallium-67 kidney uptake cutoff of 1 gave a negative predictive value of 100%, whereas a cutoff of 5 had an excellent specificity and positive predictive value for the diagnosis of AIN. When using a cutoff of 3, which had previously been used in the literature, we obtained a sensitivity of 61% and a specificity of 75% with posterior planar imaging. The results of both SPECT and posterior planar imaging modalities were comparable. Gallium-67 scintigraphy may be of interest in pat...Continue Reading

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Nov 7, 2014·World Journal of Nephrology·Soumeya Brachemi, Guillaume Bollée

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Citations

Jul 17, 2018·Jornal brasileiro de nefrologia : ʹorgão oficial de Sociedades Brasileira e Latino-Americana de Nefrologia·Carine Franco MorschelJosé Carlos Carraro Eduardo
Sep 11, 2019·Current Opinion in Critical Care·Fernando Caravaca-FontánManuel Praga
Jul 1, 2020·The Journal of Allergy and Clinical Immunology. in Practice·Douglas B JohnsonMeghan E Sise

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Methods Mentioned

BETA
biopsies
biopsy

Software Mentioned

SAS

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