The Use of Gene Therapy for Ablation of Atrial Fibrillation

Arrhythmia & Electrophysiology Review
Zhao Liu, J Kevin Donahue

Abstract

Atrial fibrillation is the most common clinically significant cardiac arrhythmia, increasing the risk of stroke, heart failure and morbidity and mortality. Current therapies, including rate control and rhythm control by antiarrhythmic drugs or ablation therapy, are moderately effective but far from optimal. Gene therapy has the potential to become an attractive alternative to currently available therapies for atrial fibrillation. Various gene transfer vectors have been developed for cardiovascular disease with viral vectors being most widely used due to their high efficiency. Several gene delivery methods have been employed on different therapeutic targets. With increasing understanding of arrhythmia mechanisms, novel therapeutic targets have been discovered. This review will evaluate state-of-art gene therapy strategies and approaches including sinus rhythm restoration and ventricular rate control that could eventually prevent or eliminate atrial fibrillation in patients.

Citations

Dec 26, 2018·Circulation Research·Li NiXander H T Wehrens
Dec 14, 2018·Journal of Neurosurgery·Alexis Dimitriadis, Ian Paddick
Oct 28, 2019·International Journal of Molecular Sciences·Vera PaarLukas J Motloch
Dec 14, 2019·Journal of Applied Clinical Medical Physics·Yuan XuJianrong Dai
Jul 30, 2020·Journal of Applied Clinical Medical Physics·Dharmin D DesaiE L Johnson
Oct 24, 2018·Journal of Cardiovascular Development and Disease·Melad FarrahaEddy Kizana
Sep 26, 2019·Frontiers in Cardiovascular Medicine·Joseph S Piktel, Lance D Wilson
Aug 24, 2019·International Journal of Cardiology·Amar TrivediRishi Arora
Apr 11, 2020·Journal of the American College of Cardiology·Mina K ChungUNKNOWN ACC Electrophysiology Section Leadership Council
Jun 3, 2021·Journal of Clinical Medicine·Paweł Muszyński, Tomasz A Bonda
May 31, 2021·Journal of Cardiovascular Electrophysiology·Shin YooRishi Arora

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