PMID: 8940980Nov 1, 1996Paper

The use of glucan as immunostimulant in the treatment of paracoccidioidomycosis

The American Journal of Tropical Medicine and Hygiene
D A MeiraP R Curi

Abstract

A group of 10 patients, nine of them seriously infected with Paracoccidioides brasiliensis (G1), received glucan (beta-1,3 polyglucose) as an immunostimulant intravenously once a week for one month, followed by monthly doses (10 mg) over an 11-month period, together with a specific anti-fungal agent as an immunostimulant. A second group of eight moderately infected patients (G2) was treated with only the anti-fungal agent. Among the patients in G1, there was only one case of relapse compared with five in G2. Values for the erythrocyte sedimentation rate (ESR) showed a significant difference (P < 0.001) post-treatment in G1 patients, when compared with the pretreatment levels. There was also a significant reduction (P < 0.001) in the level of serum antibodies to P. brasiliensis in the G1 patients in post-treatment examinations. The phytohemagglutinin (PHA) skin test showed a positive reaction among the patients in G1 (P < 0.01) post-treatment and there was a tendency towards an increase in the number of CD4+ T lymphocytes in both groups after treatment. The serum level of tumor necrosis factor (TNF) proved to be significantly higher (P < 0.02) in the G1 patients during treatment. In the G1 patients, the correlation between ESR a...Continue Reading

Citations

Mar 13, 2008·PLoS Neglected Tropical Diseases·Leandro Licursi de OliveiraAdemilson Panunto-Castelo
Apr 30, 2013·International Journal of Dermatology·Natália Galvão GarciaJoão Adolfo Costa Hanemann
Oct 16, 2015·Revista Do Instituto De Medicina Tropical De São Paulo·Maria Aparecida Shikanai-Yasuda
Sep 18, 2016·Medical Mycology·Taise Natali LandgrafAdemilson Panunto-Castelo
Aug 2, 2018·Anais Brasileiros De Dermatologia·Arival Cardoso de Brito, Maraya de Jesus Semblano Bittencourt
Aug 31, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·A Casadevall, L A Pirofski
Jan 20, 2006·Critical Reviews in Biotechnology·Djordje B ZekovićColm A Moran
May 3, 2013·Mycopathologia·Flavio Queiroz-Telles, Daniel Wagner de C L Santos
Nov 20, 2016·Clinical Microbiology Reviews·Flavio Queiroz-TellesThomas J Walsh
Dec 6, 2017·The Open Microbiology Journal·Rinaldo Poncio MendesAdriele Dandara Levorato
Jun 12, 2009·Critical Reviews in Microbiology·S SoltanianP Bossier
Mar 30, 2005·Expert Opinion on Pharmacotherapy·Maria Aparecida Shikanai Yasuda
Sep 6, 2017·International Journal of Molecular Sciences·Khawaja Muhammad Imran Bashir, Jae-Suk Choi
Jan 1, 2018·Anais Brasileiros De Dermatologia·Arival Cardoso de Brito, Fernanda Ventin Prates
May 24, 2006·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Rodrigo Juliano OliveiraMário Sérgio Mantovani
Oct 24, 2006·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Rodrigo Juliano OliveiraLúcia Regina Ribeiro
Jan 5, 2010·Vaccine·Alice M RibeiroMaria Sueli S Felipe

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