The use of gonadotropins for the induction of ovulation in women with polycystic ovarian disease

Fertility and Sterility
S G RajM L Taymor


Ten infertile patients with polycystic ovarian disease were treated with 18 cycles of "pure" human pituitary follicle-stimulating hormone (HP-FSH) and 10 cycles of human menopausal gonadotropin (HMG) consisting of FSH and luteinizing hormone (LH) in a 1:1 ratio. Human chorionic gonadotropin was used to trigger ovulation when optimal follicular development was achieved as judged by urinary estrogen determinations. Of the 18 cycles utilizing HP-FSH, 14 were presumptively ovulatory, 2 were conceptual, and in 5 cycles ovarian enlargement was noted. Of the 10 HMG cycles, none was ovulatory, no conceptions resulted, and 6 instances of hyperstimulation were noted. Pretreatment serum LH levels were significantly higher than normal follicular phase values. These observations suggest that endogenous LH levels in patients with polycystic ovaries are quite adequate for follicular development so that the administration of exogenous LH is unwarranted. Furthermore, the data suggest that HP-FSH or low-LH-containing HMG may prove to be an additional safe and effective nonsurgical treatment modality for patients who are anovulatory because of polycystic ovaries.


Aug 1, 1989·Clinical Endocrinology·H M BucklerD L Healy
Mar 1, 1991·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·J Ginsburg, P Hardiman
Feb 1, 1981·The Australian & New Zealand Journal of Obstetrics & Gynaecology·J S Biggs
Feb 1, 1980·Clinical Endocrinology·S S Yen
Mar 1, 1996·Clinical Obstetrics and Gynecology·M J Nachtigall, L B Schwartz

Related Concepts

Estrogen Effect
Follicle Stimulating Hormone
Subfertility, Female
Ovarian Stimulation
Sclerocystic Ovaries

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