The use of heparan sulfate to augment fracture repair in a rat fracture model

Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
Rebecca A JacksonSimon M Cool

Abstract

Fracture healing is a complex process regulated by numerous growth and adhesive factors expressed at specific stages during healing. The naturally occurring, cell surface-expressed sugar, heparan sulfate (HS), is known to bind to and potentiate the effects of many classes of growth factors, and as such, may be a potential candidate therapy for enhancing bone repair. This study investigated the local application of bone-derived HS in the repair of rat femoral fractures. After 2 weeks, there was a significant increase in the callus size of rats administered with 5 microg HS compared to the control and 50 microg HS groups, presumably due to increased trabecular bone volume rather than increased cartilage production. In addition, 5 microg HS increased the expression of ALP, Runx2, FGF-1, IGF-II, TGF-beta1, and VEGF. It is hypothesized that these increases resulted from changes in HS-mediated receptor/ligand interactions that increase local growth factor production to augment bone formation. The findings of this study demonstrate the anabolic potential of HS in bone repair by recruiting and enhancing the production of endogenous growth factors at the site of injury.

References

Dec 1, 1987·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A M ParfittR R Recker
Jan 1, 1984·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·F Bonnarens, T A Einhorn
Jan 1, 1994·Journal of Biomaterials Science. Polymer Edition·S BerradaM F Harmand
Nov 1, 1994·The Journal of Experimental Medicine·S M Wahl
Dec 1, 1995·Bone·F BlanquaertJ P Caruelle
Jan 23, 1998·Developmental Dynamics : an Official Publication of the American Association of Anatomists·E D LitwackA D Lander
Aug 25, 1999·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·M L RadomskyJ W Poser
Nov 11, 1999·Journal of Biomedical Materials Research·L ChunS Goodman
May 18, 2000·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·M F Sciadini, K D Johnson
Jun 29, 2000·Annual Review of Biochemistry·M BernfieldM Zako
Jul 11, 2000·Pharmaceutical Research·J E BabenseeA G Mikos
Aug 8, 2001·The Journal of Clinical Investigation·J T Gallagher
Mar 12, 2004·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Hugo SchmoekelJeffrey A Hubbell
Sep 6, 2005·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Negin AmanatDavid G Little

❮ Previous
Next ❯

Citations

Aug 4, 2007·Journal of Molecular Histology·Victor NurcombeSimon M Cool
Nov 9, 2012·Journal of Materials Science. Materials in Medicine·Gerjon HanninkPieter Buma
Apr 2, 2011·Journal of Shoulder and Elbow Surgery·Marlis T SaboGraham J W King
Jan 30, 2007·Biomaterials·Emma Luong-VanSimon Cool
Dec 10, 2008·Journal of Biomedical Materials Research. Part a·Chong Shuan TanLisbeth Grøndahl
Dec 10, 2008·Journal of Biomedical Materials Research. Part a·Ck A WuA I Cassady
Dec 8, 2015·Mediators of Inflammation·Christophe DesterkeMarie-Caroline Le Bousse-Kerdilès
Jun 20, 2014·Tissue Engineering. Part a·Nesrine Z MostafaMichael R Doschak
Dec 23, 2017·Materials·Bach Quang LeVanessa Lydia Simone LaPointe
Dec 7, 2017·Advanced Healthcare Materials·Jelena Rnjak-KovacinaMegan S Lord
Sep 25, 2017·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Lynn YapSimon M Cool
Sep 25, 2009·Journal of Cellular Biochemistry·Sadasivam MuraliVictor Nurcombe
Jan 28, 2020·Journal of the Chinese Medical Association : JCMA·Po-Yu ChiuYa-Pei Chang
Aug 2, 2018·PloS One·Philippa M BennettJowan G Penn-Barwell
Jul 3, 2021·Journal of Basic and Clinical Physiology and Pharmacology·Herry WibowoSyaifullah Asmiragani

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.