The use of hormonal growth factors in the treatment of patients with short-bowel syndrome.

Drugs
Palle Bekker Jeppesen

Abstract

To date, the hormonal factors used in the treatment of patients with short-bowel syndrome have been growth hormone and glucagon-like peptide (GLP)-2. In high-dose growth hormone studies, the effects on wet-weight absorption of approximately 0.7 kg/day have mainly been described in short-bowel syndrome patients with a preserved colon who also received oral rehydration solutions. Treatment with high doses of growth hormone is associated with severe adverse effects in the majority of patients. Low-dose growth hormone increased energy absorption by approximately 1.8 MJ/day in a group of 12 short-bowel syndrome patients (9 with a preserved colon), but it did not affect wet-weight absorption. Growth hormone does not seem to affect either wet-weight or energy absorption in patients with a jejunostomy. GLP-2 and the analogue teduglutide mainly affect wet-weight absorption, resulting in a mean increase in wet-weight absorption of 0.4-0.7 kg/day. The effects on energy absorption are minor at 0.4-0.8 MJ/day. However, these effects are seen in all short-bowel syndrome patients, regardless of anatomy, and the adverse effects are minor. In all studies employing growth hormone or GLP-2, the effects are transient, disappearing when treatments ...Continue Reading

Citations

Jan 26, 2007·Langenbeck's Archives of Surgery·Felix BraunFred Faendrich
Jan 17, 2012·Current Problems in Surgery·Jon S ThompsonDavid F Mercer
May 31, 2011·The Surgical Clinics of North America·Jon S ThompsonDavid F Mercer
Sep 6, 2008·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Cindy C TaiSaverio Bellusci
Apr 30, 2021·Expert Review of Proteomics·Noemi ZorzettiAugusto Lauro
Jul 10, 2021·World Journal of Gastroenterology : WJG·Aysegül AksanJürgen Stein

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