PMID: 6540194Jul 1, 1984Paper

The use of human cancer cell lines as a primary screening system for antineoplastic compounds

European Journal of Cancer & Clinical Oncology
G J Finlay, B C Baguley

Abstract

Exponentially growing cells of human cancer lines have been utilized to investigate the cytotoxic activity of antineoplastic agents. Different cancer cell lines differ greatly in their responsiveness to both clinical and experimental cytotoxic drugs. For example, sensitivities to 5-fluorouracil and cytosine arabinoside ranged over 15- and 30-fold respectively. Cell lines derived from carcinomas were more sensitive to 5-fluorouracil and less sensitive to cytosine arabinoside than was a leukaemic cell line. In general, colon carcinoma lines were most resistant to DNA-intercalating drugs, and a breast carcinoma and leukaemia line most sensitive. In a congeneric series of amsacrine analogues, in vitro patterns of activity against different lines were shown to correlate with activity against the Lewis lung mouse carcinoma in vivo. Results suggest that established cell lines manifest responsiveness to anticancer drugs consistent with that expected from their tumours of origin. This assay is economical, reproducible and convenient, and could be used to complement the human tumour stem cell assay in drug development studies.

References

May 1, 1979·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·I KeydarH J Brenner
Sep 1, 1980·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·I W Taylor
Nov 1, 1983·European Journal of Cancer & Clinical Oncology·B C BaguleyW R Wilson
Nov 1, 1956·The American Journal of Medicine·H EAGLE, G E FOLEY

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Citations

Jan 1, 1992·Journal of Cancer Research and Clinical Oncology·G BernhardtH Schönenberger
Jul 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·R A VescioR M Hoffman
Jun 1, 1987·European Journal of Cancer & Clinical Oncology·B C Baguley, W R Wilson
Sep 1, 1989·European Journal of Cancer & Clinical Oncology·D T LileyB C Baguley
Oct 13, 2017·Journal of Cellular Physiology·Francesco P FiorentinoIrene Marchesi

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