PMID: 22553814May 4, 2012Paper

The use of immunohistochemical expression of SF-1 and EMA in distinguishing adrenocortical tumors from renal neoplasms

Applied Immunohistochemistry & Molecular Morphology : AIMM
Miriam L EnriquezZhanyong Bing

Abstract

Steroidogenic factor -1 (SF-1) is an orphan member of the nuclear hormone receptor superfamily, and is considered to play an important role in the differentiation of steroidogenic tissues. In this study, we compared the immunohistochemical stains of SF-1 and epithelial membrane antigen (EMA) in non-neoplastic adrenal tissue, and adrenal and renal tumors using tissue microarrays (TMAs). The adrenal tissue array included 19 cases of normal adrenal cortex, 22 cases of adrenal adenoma, and 20 cases of adrenal cortical carcinoma. The renal tissue array included 20 cases of each of the following types of renal cell carcinoma: clear cell, papillary, and chromophobe. In addition, 20 cases of renal oncocytoma were also included in the study. SF-1 showed positive staining in all cases (100%) of normal adrenal cortex and adrenal cortical adenoma, and in 18 (90%) cases of adrenocortical carcinoma. In renal tumors, SF-1 showed negative stains in all of oncocytoma, papillary, and chromophobe renal cell carcinoma. Only 3 out of 20 cases of clear cell renal cell carcinoma showed weak positivity in approximately 10% of tumor cells. EMA stained positively in 85%, 95%, 100%, and 95% of clear cell, papillary, chromophobe renal cell carcinomas, and...Continue Reading

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Citations

Nov 27, 2014·Archives of Pathology & Laboratory Medicine·Myra L WilkersonLiang Cheng
Nov 27, 2014·Archives of Pathology & Laboratory Medicine·Fan Lin, Haiyan Liu
Feb 19, 2015·Virchows Archiv : an International Journal of Pathology·Hongmei LiKenneth A Iczkowski
May 21, 2018·Endocrine Pathology·Veronica K Y CheungAngela Chou
Aug 7, 2019·Archives of Pathology & Laboratory Medicine·Si Kei, Oyedele A Adeyi
Jul 16, 2021·Rare Tumors·Rui Caetano OliveiraMaria Augusta Cipriano
Sep 1, 2021·American Journal of Clinical Pathology·Salam AshourJesse K McKenney

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