The use of in vitro model systems to study dental biofilms associated with caries: a short review

Journal of Oral Microbiology
Krista M Salli, Arthur C Ouwehand

Abstract

A dental biofilm forms a distinct environment where microorganisms live in a matrix of extracellular polysaccharides. The biofilm favors certain bacteria and creates a habitat that functions differently compared to planktonic bacteria. Reproducible model systems which help to address various questions related to biofilm formation, the process of caries development, and its prevention are needed and are continuously developed. Recent research using both batch culture, continuous culture and flow cells in caries biofilm formation is presented. The development of new techniques and equipment has led to a deeper understanding of how caries biofilms function. Biofilm models have also been used in the development of materials inhibiting secondary caries. This short review summarizes available models to study these questions.

References

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Citations

Jul 8, 2015·Journal of Microbiological Methods·Bruce TepperJian Xu
Dec 12, 2017·Medical Mycology·Marlene ChevalierIsabelle Prêcheur
Mar 15, 2016·AMB Express·Samuel P ForryMadeleine D Pasco
Jan 10, 2019·Journal of Applied Oral Science : Revista FOB·Daiana Moreli Soares Dos SantosAna Carolina Magalhães
Mar 21, 2019·Brazilian Oral Research·Felipe Weidenbach DegraziaFabrício Mezzomo Collares
Aug 7, 2019·International Journal of Molecular Sciences·Cristina Cattò, Francesca Cappitelli
Dec 23, 2020·Biofouling·Débora de Souza Collares Maia Castelo-BrancoJosé Júlio Costa Sidrim
Apr 23, 2021·Photodiagnosis and Photodynamic Therapy·Maíra Terra-GarciaJuliana Campos Junqueira
Jun 19, 2021·NPJ Biofilms and Microbiomes·Birte HollmannKim R Hardie
Jun 26, 2021·Journal of Dental Research·A A BalhaddadM A S Melo
Apr 17, 2020·ACS Applied Materials & Interfaces·Jian Rong ChongKeitaro Sou

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Methods Mentioned

BETA
scanning electronic microscopy
electrophoresis

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