The use of inhaled prostaglandins in patients with ARDS: a systematic review and meta-analysis

Chest
Brian M FullerChristopher R Carpenter

Abstract

This study aimed to determine whether inhaled prostaglandins are associated with improvement in pulmonary physiology or mortality in patients with ARDS and assess adverse effects. The following data sources were used: PubMed, EMBASE, CINAHL, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, reference lists, conference proceedings, and ClinicalTrials.gov. Studies selected included randomized controlled trials and nonrandomized studies. For data extraction, two reviewers independently screened titles and abstracts for eligibility. With regard to data synthesis, 25 studies (two RCTs) published over 21 years (1993-2014) were included. The PROSPERO registration number was CRD42014013180. One randomized controlled trial showed no difference in the change in mean Pao2 to Fio2 ratio when comparing inhaled alprostadil to placebo: 141.2 (95% CI, 120.8-161.5) to 161.5 (95% CI, 134.6-188.3) vs 163.4 (95% CI, 140.8-186.0) to 186.8 (95% CI, 162.9-210.7), P = .21. Meta-analysis of the remaining studies demonstrated that inhaled prostaglandins were associated with improvement in Pao2 to Fio2 ratio (16 studies; 39.0% higher; 95% CI, 26.7%-51.3%), and Pao2 (eight studies; 21.4% higher; 95% CI, 12.2%-30.6%),...Continue Reading

References

Mar 3, 1977·The New England Journal of Medicine·W M Zapol, M T Snider
Aug 1, 1992·The American Review of Respiratory Disease·P J SloaneJ E Fish
Oct 1, 1990·American Journal of Respiratory Cell and Molecular Biology·C M RivaL A Boxer
Jun 15, 1983·Biochemical and Biophysical Research Communications·J C Fantone, D A Kinnes
Jan 1, 1984·Respiration; International Review of Thoracic Diseases·O C BurghuberC Leithner
Mar 1, 1994·American Journal of Respiratory and Critical Care Medicine·G R BernardR Spragg
Jun 2, 1993·JAMA : the Journal of the American Medical Association·D J CookA D Oxman
Mar 1, 1996·American Journal of Respiratory and Critical Care Medicine·D WalmrathW Seeger
Dec 1, 1996·American Journal of Respiratory and Critical Care Medicine·B ZwisslerK Peter
Jun 25, 1998·American Journal of Respiratory and Critical Care Medicine·C PutensenG Putensen-Himmer
May 4, 2000·The New England Journal of Medicine·UNKNOWN Acute Respiratory Distress Syndrome NetworkArthur Wheeler
Jul 12, 2002·Statistics in Medicine·Julian P T Higgins, Simon G Thompson
Sep 6, 2003·BMJ : British Medical Journal·Julian P T HigginsDouglas G Altman
Apr 8, 2004·JAMA : the Journal of the American Medical Association·Robert W TaylorUNKNOWN Inhaled Nitric Oxide in ARDS Study Group
Oct 21, 2005·The New England Journal of Medicine·Gordon D RubenfeldLeonard D Hudson
Mar 27, 2007·BMJ : British Medical Journal·Neill K J AdhikariMaureen O Meade
Nov 17, 2007·Paediatric Respiratory Reviews·P DahlemA P Bos
Jul 1, 2009·Pediatrics·Jerry J ZimmermanGordon D Rubenfeld
Oct 14, 2009·JAMA : the Journal of the American Medical Association·UNKNOWN Australia and New Zealand Extracorporeal Membrane Oxygenation (ANZ ECMO) Influenza InvestigatorsMarc Ziegenfuss
Feb 26, 2010·Journal of Burn Care & Research : Official Publication of the American Burn Association·Patrick F AllanSteven V Silvey
Feb 25, 2011·Journal of Public Health·Rebecca ArmstrongElizabeth Waters
Jul 12, 2011·Critical Care Clinics·Nitin Puri, Richard Phillip Dellinger
Jul 26, 2011·BMJ : British Medical Journal·Jonathan A C SterneJulian P T Higgins
Sep 29, 2012·The Journal of Trauma and Acute Care Surgery·Maryam Bita TabriziAndrew J Kerwin
May 21, 2013·Journal of Critical Care·Heather TorbicGerald Weinhouse
Nov 21, 2013·Respiratory Care·Jose PachecoMarin H Kollef

❮ Previous
Next ❯

Citations

Nov 26, 2015·Current Opinion in Anaesthesiology·Sandra HoeglChristine Vohwinkel
Oct 19, 2016·Clinical and Experimental Emergency Medicine·Brian J Wright
Jan 4, 2017·American Journal of Respiratory and Critical Care Medicine·Hemang YadavOgnjen Gajic
Aug 15, 2017·The Cochrane Database of Systematic Reviews·Arash AfshariMikkel Allingstrup
Jun 13, 2018·The Annals of Pharmacotherapy·Mahmoud A AmmarSimon W Lam
Mar 8, 2019·Expert Opinion on Emerging Drugs·Timothy D ShawCecilia M O'Kane
Feb 23, 2019·Journal of Pharmacy Practice·Mitchell S BuckleyJeffrey P Gonzales
Apr 9, 2020·Journal of Intensive Care Medicine·Jeremy B RichardsSusan R Wilcox
Aug 25, 2020·Research and Practice in Thrombosis and Haemostasis·Hunter B MooreMichael B Yaffe
Aug 19, 2020·Critical Care : the Official Journal of the Critical Care Forum·Jie LiRajiv Dhand
Aug 27, 2019·Critical Care Nursing Quarterly·Sheng FuValentyna Ivanova
Aug 14, 2020·Expert Opinion on Pharmacotherapy·Maria Gabriella MateraMario Cazzola
Nov 26, 2020·Journal of Intensive Care Medicine·Rajiv SontiNathan Cobb
Dec 8, 2020·Pulmonary Circulation·Veronica FrancoRaymond L Benza
Jun 9, 2020·Current Problems in Surgery·Nathan T MoweryAdam C Nelson
Mar 31, 2021·Journal of Cardiothoracic and Vascular Anesthesia·Carson WelkerHarish Ramakrishna
Oct 20, 2020·The American Journal of Emergency Medicine·Skyler LentzBrit Long
Jul 5, 2021·Lancet·Nuala J MeyerCarolyn S Calfee
Sep 17, 2021·The Egyptian Heart Journal : (EHJ) : Official Bulletin of the Egyptian Society of Cardiology·Eka Prasetya Budi Mulia, Kevin Luke
Dec 22, 2021·Hämostaseologie·Laura Castiglione, Michal Droppa

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.