The use of insulin detemir during pregnancy: a safety evaluation

Expert Opinion on Drug Safety
Ronit KorenMoshe Hod

Abstract

Diabetes during pregnancy causes both fetal and maternal complications. Insulin is the most effective pharmacological treatment for controlling hyperglycemia during gestation and can limit adverse outcomes. Insulin detemir (IDet), a novel basal insulin, has already been used for this indication for several years. It was reclassified in 2012 by the FDA from category C to category B for the treatment of pregnant women with diabetes. This article reviews published data regarding the use of IDet during pregnancy. We discuss pharmacokinetic and pharmacodynamic qualities of IDet and potential advantages for its use during pregnancy. IDet is a viable option for the management of diabetes during pregnancy. Though data is limited, its safety and efficacy is probably comparable to human insulin, and in some aspects superior to it. More data, specifically for IDet in pregnancies complicated by gestational diabetes (GDM) or type 2 diabetes, is needed.

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Citations

May 5, 2016·Expert Opinion on Drug Safety·Yoel ToledanoMoshe Hod
Jun 24, 2017·Obstetrics and Gynecology·UNKNOWN Committee on Practice Bulletins—Obstetrics
Aug 24, 2018·Expert Opinion on Pharmacotherapy·Angelo Maria PattiNikolaos Papanas
Sep 3, 2017·Drugs·Geetha Mukerji, Denice S Feig
Jan 26, 2018·Obstetrics and Gynecology·UNKNOWN Committee on Practice Bulletins—Obstetrics
May 11, 2019·Current Diabetes Reports·Laura T Dickens, Celeste C Thomas
Apr 14, 2016·Biomedical Reports·David Calderón GuzmánNorma Osnaya Brizuela

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