The Use of Interferon Gamma Inducible Protein 10 as a Potential Biomarker in the Diagnosis of Latent Tuberculosis Infection in Uganda

PloS One
Irene Andia BiraroAchilles Katamba

Abstract

In the absence of a gold standard for the diagnosis of latent tuberculosis (TB) infection (LTBI), the current tests available for the diagnosis of LTBI are limited by their inability to differentiate between LTBI and active TB disease. We investigated IP-10 as a potential biomarker for LTBI among household contacts exposed to sputum positive active TB cases. Active TB cases and contacts were recruited into a cohort with six months' follow-up. Contacts were tested for LTBI using QuantiFERON®-TB Gold In-Tube (QFN) assay and the tuberculin skin test (TST). Baseline supernatants from the QFN assay of 237 contacts and 102 active TB cases were analysed for Mycobacterium tuberculosis (MTB) specific and mitogen specific IP-10 responses. Contacts with LTBI (QFN+TST+) had the highest MTB specific IP-10 responses at baseline, compared to uninfected contacts (QFN-TST-) p<0.0001; and active cases, p = 0.01. Using a cut-off of 8,239 pg/ml, MTB specific IP-10 was able to diagnose LTBI with a sensitivity of 87.1% (95% CI, 76.2-94.3) and specificity of 90.9% (95% CI, 81.3-96.6). MTB specific to mitogen specific IP-10 ratio was higher in HIV negative active TB cases, compared to HIV negative latently infected contacts, p = 0.0004. Concentrations...Continue Reading

References

Jan 5, 1999·American Journal of Respiratory and Critical Care Medicine·D Menzies
Jun 24, 1999·Immunology Today·I M Orme, A M Cooper
Jun 30, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·D F HoftR B Belshe
Sep 29, 2000·Lancet·P AndersenT M Doherty
Mar 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jennifer H DufourAndrew D Luster
Dec 6, 2002·The New England Journal of Medicine·Robert M JasmerPhilip C Hopewell
May 14, 2003·Archives of Internal Medicine·Elizabeth L CorbettChristopher Dye
May 30, 2003·American Journal of Respiratory and Critical Care Medicine·Christian LienhardtSteve Bennett
Mar 23, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Philip C HillKeith P W J McAdam
Apr 3, 2004·American Journal of Respiratory and Critical Care Medicine·Toru MoriIzuo Tsuyuguchi
Apr 17, 2004·American Journal of Respiratory and Critical Care Medicine·Inger BrockPeter Andersen
Nov 30, 2004·The Lancet Infectious Diseases·Madhukar PaiJohn M Colford
May 4, 2006·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Nobuyuki HaradaToru Mori
Jun 27, 2006·American Journal of Respiratory and Critical Care Medicine·Luca Richeldi
Dec 2, 2008·The European Respiratory Journal·A Lalvani, K A Millington
Mar 5, 2010·Respirology : Official Journal of the Asian Pacific Society of Respirology·Christoph Lange, Toru Mori
May 18, 2010·The Journal of Infection·Delia GolettiPhilippe Henri Lagrange
Jul 12, 2011·The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·P WeinfurterUNKNOWN Tuberculosis Epidemiological Studies Consortium
Mar 1, 2012·Expert Review of Molecular Diagnostics·Morten RuhwaldPernille Ravn

❮ Previous
Next ❯

Citations

Nov 2, 2019·BMC Infectious Diseases·Xia QiuDezhi Mu
Oct 11, 2016·Pediatric Research·Sutapa KhatuaAnand Gourishankar
Apr 30, 2019·Expert Review of Proteomics·Deepa BishtVivek Kumar Gupta
Jul 1, 2021·Clinical & Translational Immunology·Jessica L PedersenBernadette M Saunders

❮ Previous
Next ❯

Methods Mentioned

BETA
ELISA

Software Mentioned

Gen5 [UNK] Data Analysis

Related Concepts

Related Feeds

Related Papers

The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease
Y-W HuangW-T Yang
International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases
Ji Young HongYoung Ae Kang
© 2022 Meta ULC. All rights reserved