The use of intravenous methotrexate in the treatment of ectopic pregnancy

Journal of Chemotherapy
E PeritiG Amunni

Abstract

Between January 1996 and December 2001, at the Department of Gynecology, Perinatology and Human Reproduction of the University of Florence, 49 ectopic pregnancies were submitted to medical treatment. The treatment schedule consisted of the administration of 100 mg of intravenous methotrexate (MTX). The patients included in this study fulfilled the following requisites: gestational period <8 weeks; diameter of the ectopic gestational sac <4 cm; serum level of human chorionic beta-gonadotropin (beta-hCG) <5000 IU/ml; absence of clinical and ultrasound signs of tube rupture with initial hemoperitoneum; hematochemical tests compatible with chemotherapic treatment. All patients were followed with a dosage of serum beta-hCG repeated every 2-3 days after chemotherapy and with an ultrasound every 3-4 days. In case of documented success of treatment the patient was hospitalized for no more than 3 days after administration of the drug. In 1 case therapy took place in a day-hospital regimen. Medical treatment was effective in 35 patients out of 49 (71.4%) and led to negative beta-hCG in a median time of 11 days, with a range between 2 and 48 days. In the 14 non-responsive cases (28.6%), after a mean time of 6 days we proceeded to a tradit...Continue Reading

References

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Citations

Aug 4, 2007·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Eyad Al-SalehMoorkath Nandakumaran
Nov 13, 2009·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·E Al-SalehW Al-Jassar
Aug 28, 2012·Annals of Emergency Medicine·Sigrid A HahnUNKNOWN American College of Emergency Physicians Clinical Policies Subcommittee on Early Pregnancy
Apr 28, 2006·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Amy TangSoo Keat Khoo
Dec 24, 2005·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·E KirkT Bourne

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