PMID: 6402287Apr 1, 1983Paper

The use of intravenous phenylalanine mustard followed by supervoltage irradiation in the treatment of carcinoma of the ovary

Cancer
J E NevinJ J Marsella

Abstract

Between 1970 and 1980, 50 patients with carcinoma of the ovary were treated sequentially with six courses of IV phenylalanine mustard (L-PAM), second look surgery, and radiotherapy using the strip technique. Seven patients had advanced Stage I disease and six patients had Stage II disease; all of these patients are alive and well with no evidence of disease (NED) with a mean survival of five years. Thirty-seven patients had Stage III disease: ten of these patients did not respond to L-PAM (26%); 17 patients had a partial response (48%), and four of these (22%) are alive with NED and a mean survival of five years; ten patients (26%) had a complete response to L-PAM and all are alive and well with a mean survival of five years. The presence of a minimal tumor burden after the initial surgery, a mixed histology, a low-grade differentiation, suppression of leukocyte count to below 2000/mm3 after the first course of chemotherapy, and a complete response to L-PAM, were all factors that contributed to the probability of a long-term survival. Tumors responding to L-PAM and then recurring also responded to a combination of cisplatin and adriamycin, and hexamethylmelamine.

References

Feb 1, 1977·Cancer·R I Fisher, R C Young
Apr 8, 1976·The New England Journal of Medicine·J S Tobias, C T Griffiths
Aug 1, 1975·Cancer·R E Symmonds
Aug 1, 1975·Cancer·J P Smith, F Rutledge
Jun 1, 1967·American Journal of Obstetrics and Gynecology·B C BurnsL Declclos
Aug 1, 1970·American Journal of Obstetrics and Gynecology·R W Smith
Dec 1, 1972·Cancer·J P SmithJ T Wharton
Oct 26, 1972·The New England Journal of Medicine·C M BagleyV T DeVita
May 15, 1973·American Journal of Obstetrics and Gynecology·M J WebbT J Williams
Jan 1, 1974·The American Journal of Roentgenology, Radium Therapy, and Nuclear Medicine·J T Fazekas, J G Maier
Apr 1, 1968·American Journal of Obstetrics and Gynecology·G D MalkasianC E Johnson
Dec 15, 1965·American Journal of Obstetrics and Gynecology·J G Masterson, J H Nelson
Oct 1, 1963·Radiology·L DELCLOSE VANROOSENBEEK
Sep 1, 1960·American Journal of Obstetrics and Gynecology·S W KENT, D G MCKAY

❮ Previous
Next ❯

Citations

Jan 1, 1984·Journal of Cancer Research and Clinical Oncology·R GreinerP Veraguth
Jan 1, 1984·Journal of Cancer Research and Clinical Oncology·R M Canetta, S K Carter
May 1, 1987·American Journal of Obstetrics and Gynecology·J T SoperW T Creasman
Apr 1, 1985·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·S RizelZ Fuks
Nov 1, 1986·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·E M RosenL E Botnick
Sep 1, 1988·Gynecologic Oncology·K C PodratzT O Wilson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.