PMID: 8938626Oct 1, 1996Paper

The use of isoflurane anaesthesia in studies of carnitine metabolism in the laboratory rat

Laboratory Animals
A T Davis

Abstract

The purpose of this study was to investigate the effect of isoflurane anaesthesia in the rat prior to decapitation on metabolites of interest in studies of carnitine metabolism. Male and female fed and starved rats were allocated to either the decapitation group, or to the anaesthesia-decapitation group. Six animals were allocated to each treatment. Within each gender and within feeding status, there were no significant effects of isoflurane anaesthesia with regard to plasma and liver carnitine, plasma beta-hydroxybutyrate and free fatty acids, or liver free fatty acids, triglycerides, free CoA, and acetyl CoA (P > 0.05). It was concluded that isoflurane anaesthesia can be used in studies of carnitine metabolism where the rat is used as a model.

Citations

Aug 28, 2009·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·Indroneal BanerjeeTroy A Baudino
Dec 24, 2013·Biochimica Et Biophysica Acta·Henriqueta Dias CardosoBelmira Lara da Silveira Andrade-da-Costa
Jan 20, 2018·American Journal of Physiology. Endocrinology and Metabolism·Eunsook S JinCraig R Malloy
Feb 12, 1998·The British Journal of Dermatology·A B LansdownA Vuttivirojana

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