The use of konjac glucomannan hydrolysates to recover healthy microbiota in infected vaginas treated with an antifungal agent

Beneficial Microbes
Richard F TesterM Tang

Abstract

The aim of this study was to evaluate how konjac glucomannan hydrolysates (GMH) could support the healthy re-colonisation of vaginal microflora post infections. A total of 26 female patients (12 controls and 14 treatments) aged 18 to 25 suffering from vaginal infection were recruited for this study. Patients were assigned randomly into two groups to receive a standard antifungal treatment or a standard antifungal treatment plus pessary capsules containing 200 mg GMH (twice a week for thirty days). Patients were assessed on day zero, sixteen and thirty of the trial. Several parameters were determined including yeast and bacterial counts, the KOH test, pH, Gram staining and wet mount microscopic observations. The results showed that the counts of Candida were diminished completely with antifungal treatment for both groups. However, the total bacterial counts increased with time in the GMH pessary group unlike the control. The normalised average KOH scores were reduced sharply with time in both groups although in the control group scores started to increase after sixteen days. The normalised average white blood cell scores also decreased with time for both groups. Epithelial cell scores decreased only for the GMH pessary group whi...Continue Reading

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Citations

Jul 16, 2014·Critical Reviews in Biotechnology·Montarop YamabhaiDietmar Haltrich
Mar 4, 2014·Beneficial Microbes·F H Al-Ghazzewi, R F Tester
Dec 18, 2015·Journal of the Science of Food and Agriculture·Richard F Tester, Farage H Al-Ghazzewi
Jan 13, 2016·Journal of Applied Microbiology·F H Al-Ghazzewi, R F Tester
Aug 3, 2016·International Journal of Biological Macromolecules·Sudhanshu S Behera, Ramesh C Ray
Oct 4, 2016·International Immunopharmacology·Ruixue LiuBo Zhang
Jun 27, 2014·PloS One·Huixin QinYing Wu
Mar 2, 2017·Journal of Agricultural and Food Chemistry·Belén GómezJosé L Alonso
Jul 5, 2018·Journal of Zhejiang University. Science. B·Min JiangZheng-Hong Xu
Dec 5, 2018·Journal of Food Science·Yan ZengYuanxia Sun
Sep 30, 2020·International Journal of Biological Macromolecules·Mehnaza ManzoorRafeeya Shams
Sep 9, 2020·Food Hydrocolloids·Katsuyoshi Nishinari, Yapeng Fang
Aug 17, 2021·Frontiers in Oncology·Wenkui DaiRuifang Wu

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