The use of lipid-based formulations to increase the oral bioavailability of Panax notoginseng saponins following a single oral gavage to rats

Drug Development and Industrial Pharmacy
Jing XiongQineng Ping

Abstract

This article was intended to improve the absorption of ginsenoside Rg1 and Rb1 of Panax notoginseng saponins (PNS). PNS-Phospholipid complex and a lipid-based formulation by dissolving the complex in the medium chain fattyglycerides were prepared, and their oral relative bioavailability was determined in rats and compared with an aqueous solution of PNS for each component. The study gave evidence that the phospholipids could combine with the two active constitutes of PNS and form a PNS-phospholipid complex. The complex efficiently increased the solubility of hydrophilic ginsenoside Rg1 and Rb1 in some selected hydrophobic esters, such as fatty glycerides, and constructed the lipid-based formulations of PNS. The experimental result in rats in vivo showed that the oral relative bioavailability was enhanced remarkably by these lipid-based formulations composed of the PNS-Phospholipid complex and various esters. The absorption enhancement of the medium-chain glyceride (Labrafac cc and Capmul MCM (3:1)) was somewhat greater than that of other fatty glyceride. The area under the plasma concentration-time curve (AUC) of ginsenoside Rg1 and Rb1 of the PNS-complex in the medium-chain glyceride were 27.38 microg.mL-1.h and 600.08 microg....Continue Reading

References

Jan 1, 1991·Pharmacology·C G BenishinH J Liu
Sep 1, 1988·Journal of Medicinal Chemistry·P BühlmayerJ M Wood
Apr 1, 1983·Journal of Pharmaceutical Sciences·I UedaJ Kozatani
Apr 1, 1994·Diabetic Medicine : a Journal of the British Diabetic Association·L HiltunenS L Kivelä
Oct 1, 1996·Planta medica·H HasegawaM Uchiyama
Aug 15, 2002·International Journal of Pharmaceutics·F CournarieC Vauthier
Oct 3, 2003·International Journal of Pharmaceutics·Kazuhiro SasakiKozo Takayama
Nov 23, 2005·International Journal of Pharmaceutics·Xiao YanyuPing Qineng
Mar 17, 2006·Acta Pharmacologica Sinica·Min Han, Xiao-Ling Fang
Mar 25, 2006·Planta medica·Min HanXiaoling Fang

❮ Previous
Next ❯

Citations

Jun 12, 2010·Chinese Medicine·Kar Wah Leung, Alice Sze-Tsai Wong
Sep 29, 2011·AAPS PharmSciTech·Paulo José SalústioHelena M Cabral Marques
Nov 16, 2010·Drug Development and Industrial Pharmacy·Zhongbin WuJianming Chen
May 31, 2011·International Journal of Pharmaceutics·Jianjun ZhangHui Zu
Sep 16, 2011·Journal of Peptide Science : an Official Publication of the European Peptide Society·Stefano PerniValeria Marsili
Jul 31, 2014·Natural Product Research·Ghulam AbbasWajahat Mahmood
Apr 15, 2016·Journal of Agricultural and Food Chemistry·Hiroyuki InagakiTatsuhiko Ito
Sep 16, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·Natasya Trivena RokotAkio Inui
Sep 4, 2016·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Kareem AbuBakr SolimanMahmoud Mohammed Ghorab
Jun 21, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Bang-Yue LuoJing-Wei Shao

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Zhongguo yao li xue bao = Acta pharmacologica Sinica
S H Li, Y Chu
Zhongguo yao li xue bao = Acta pharmacologica Sinica
K Y Jiang, Z N Qian
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials
Han-ming CuiJie Wang
Zhongguo yao li xue bao = Acta pharmacologica Sinica
L Y MaS J Dong
© 2021 Meta ULC. All rights reserved