The Use of Liquids Ionic Fluids as Pharmaceutically Active Substances Helpful in Combating Nosocomial Infections Induced by Klebsiella Pneumoniae New Delhi Strain, Acinetobacter Baumannii and Enterococcus Species

International Journal of Molecular Sciences
Andrzej MiskiewiczPaweł Kowalczyk

Abstract

This review deals with various microbiological activities of ionic liquids, which constitute the first anti-infective defense against multi-drug-resistant bacteria-with a particular emphasis placed on medicine and pharmacology. The quoted data on the biological activity of ionic liquids including their antimicrobial properties (depending on the type of a cation or an anion) and are discussed in view of possible applications in nosocomial infections. Dedicated attention is given to finding infections with the Klebsiella pneumoniae New Delhi strain, Acinetobacter baumannii, and Enterococcus species, which are responsible for the induction of antibiotic resistance in intensive care units. Diagnosis and treatment using current antibiotics is a significant problem in hospital care, and the relevant burden on the health systems of the European Union member states induces the search for new, effective methods of treatment. Ionic liquids, due to their antibacterial effect, can be considered topical and general medications and may provide the basis for treatment to eliminate the antibiotic resistance phenomenon in the future. At present, the number of infections with resistant pathogens in hospitals and outpatient clinics in the Europea...Continue Reading

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Citations

Sep 10, 2020·Antibiotics·Cristina PrudêncioRicardo Ferraz
Nov 26, 2019·Current Drug Research Reviews·Simran K ZanduInderbir Singh
Dec 30, 2020·Pharmaceuticals·Adriana VallsBelén Altava
Feb 8, 2021·Drug Discovery Today·Manuel SimõesFernanda Borges
Apr 4, 2021·Microorganisms·Corneliu Ovidiu VrancianuMariana Carmen Chifiriuc
Oct 3, 2021·Biotechnology and Bioengineering·Shivangi ParhiPaulomi Ghosh

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Methods Mentioned

BETA
neutron capture therapy
transfection
reverse-phase chromatography

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