The use of long non-coding RNAs as prognostic biomarkers and therapeutic targets in prostate cancer

Oncotarget
Cristian Arriaga-CanonLuis A Herrera

Abstract

Prostate cancer is the most common cancer in men and the second leading cause of cancer-related deaths. The most used biomarker to detect prostate cancer is Prostate Specific Antigen (PSA), whose levels are measured in serum. However, it has been recently established that molecular markers of cancer should not be based solely on genes and proteins but should also reflect other genomic traits; long non-coding RNAs (lncRNAs) serve this purpose. lncRNAs are transcripts of >200 bases that do not encode proteins and that have been shown to display abnormal expression profiles in different types of cancer. Experimental studies have highlighted lncRNAs as potential biomarkers for prognoses and treatments in patients with different types of cancer, including prostate cancer, where the PCA3 lncRNA is currently used as a diagnostic tool and management strategy. With the development of genomic technologies, particularly next-generation sequencing (NGS), several other lncRNAs have been linked to prostate cancer and are currently under validation for their medical use. In this review, we will discuss different strategies for the discovery of novel lncRNAs that can be evaluated as prognostic biomarkers, the clinical impact of these lncRNAs a...Continue Reading

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Citations

May 3, 2020·Nature Communications·Jessica M Silva-FisherChristopher A Maher
Sep 13, 2020·Non-coding RNA·Lavinia RaimondiNicola Amodio
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Dec 18, 2020·Frontiers in Genetics·Marina AznaourovaLeon N Schulte
Apr 13, 2021·Reproductive Sciences·Zahra FalahatiReza Mirfakhraie

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Methods Mentioned

BETA
biopsy
biopsies
PCR
xenografts
RNA-Seq
Antisense Oligonucleotides
Xenograft
PCA

Clinical Trials Mentioned

NCT02446444

Software Mentioned

PROGENSA
Prolaris
Oncotype DX
Decipher

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