The use of macroelectrodes in recording cellular spiking activity

Journal of Neuroscience Methods
John S WinestoneZvi Israel

Abstract

Microelectrode recording (MER) is an important navigational and investigational tool, specifically with regard to deep brain stimulation (DBS) surgery. MER is often utilized when targeting the subthalamic nucleus (STN) and other deep brain nuclei in the management of Parkinson's disease (PD), tremor, dystonia and other emerging applications. Microelectrodes are used to detect and measure cellular spiking activity while macroelectrodes are considered more suitable for measuring the collective sum of slow potentials from multiple cells near the electrode, the local field potential (LFP). Precisely how the characteristics of an electrode affect the data recorded is still unclear. Technical idiosyncrasies of some surgical cases allowed serendipitous data collection from a 250 to 6000 Hz bandpassed macroelectrode recording during DBS implantation for PD. Simultaneous recording from both a microelectrode and macroelectrode were compared along the same surgical trajectory. Audio, normalized root mean square of the recorded signal, and power spectrograms were used to analyze the data. The analyses demonstrate similar results in detecting cellular spiking activity when recording with macroelectrodes compared with microelectrodes. This h...Continue Reading

References

Feb 5, 2008·Journal of Neuroscience Methods·Matthew J NelsonJeffrey D Schall
May 23, 2009·Experimental Neurology·Moran WeinbergerJonathan O Dostrovsky
Jun 3, 2009·Brain Research·Matthew P WardPedro P Irazoqui
Jun 18, 2009·Movement Disorders : Official Journal of the Movement Disorder Society·Adam ZaidelZvi Israel
Jul 7, 2009·Annual Review of Psychology·Richard A AndersenGrant H Mulliken
Mar 12, 2010·Journal of Neurophysiology·Matthew J Nelson, Pierre Pouget

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Citations

Oct 2, 2012·Experimental Neurology·Alberto PrioriSara Marceglia
Jul 22, 2014·Movement Disorders : Official Journal of the Movement Disorder Society·Jing WangAlfons Schnitzler
Feb 22, 2014·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Anne BeuterJulien Modolo
Mar 10, 2015·Frontiers in Computational Neuroscience·Alessandra PaffiMicaela Liberti
Oct 23, 2016·Journal of Theoretical Biology·Masoud AmiriKarim Faez
Feb 17, 2017·Journal of Neurophysiology·Odeya MarmorRenana Eitan
Feb 11, 2018·Movement Disorders : Official Journal of the Movement Disorder Society·Georgios NarosAlireza Gharabaghi
Apr 3, 2019·Nature Reviews. Neurology·Walid BouthourPaul Krack

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