PMID: 8941889Nov 1, 1996Paper

The use of mannitol in severe head injury. Brain Trauma Foundation

Journal of Neurotrauma

Abstract

Mannitol is effective in reducing ICP, and we recommend its use in the management of traumatic intracranial hypertension. Serum osmolalities greater than 320 mOSsm/L and hypovolemia should be avoided. Some data suggest that bolus administration is preferable to continuous infusion.

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Citations

Jul 29, 2005·Der Orthopäde·J DöhnertC E Heyde
Feb 23, 2002·The Journal of Emergency Medicine·Robert H BirkhahnOlivia Lopez
Apr 21, 2005·Journal of Neurosurgical Anesthesiology·Renaud VialetClaude Martin
Feb 11, 2003·Critical Care Medicine·K H PoldermanA R J Girbes
Nov 3, 1998·Archives of Disease in Childhood·T Duke
Jun 14, 2006·Journal of Critical Care·Venkatesh AiyagariMichael N Diringer
Aug 3, 2001·Journal of Chromatography. B, Biomedical Sciences and Applications·A KiyoshimaN Ikeda

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Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.