The use of mass spectrometry in a proteome-centered multiomics study of human pituitary adenomas.

Mass Spectrometry Reviews
Na LiXianquan Zhan

Abstract

A pituitary adenoma (PA) is a common intracranial neoplasm, and is a complex, chronic, and whole-body disease with multicausing factors, multiprocesses, and multiconsequences. It is very difficult to clarify molecular mechanism and treat PAs from the single-factor strategy model. The rapid development of multiomics and systems biology changed the paradigms from a traditional single-factor strategy to a multiparameter systematic strategy for effective management of PAs. A series of molecular alterations at the genome, transcriptome, proteome, peptidome, metabolome, and radiome levels are involved in pituitary tumorigenesis, and mutually associate into a complex molecular network system. Also, the center of multiomics is moving from structural genomics to phenomics, including proteomics and metabolomics in the medical sciences. Mass spectrometry (MS) has been extensively used in phenomics studies of human PAs to clarify molecular mechanisms, and to discover biomarkers and therapeutic targets/drugs. MS-based proteomics and proteoform studies play central roles in the multiomics strategy of PAs. This article reviews the status of multiomics, multiomics-based molecular pathway networks, molecular pathway network-based pattern biomar...Continue Reading

References

Jan 1, 1988·Virchows Archiv. A, Pathological Anatomy and Histopathology·S YamadaK Kovacs
Jun 1, 1996·Current Opinion in Immunology·B Su, M Karin
Nov 8, 1996·Science·M R Emmert-BuckL A Liotta
Jan 19, 2000·Rapid Communications in Mass Spectrometry : RCM·S Beranova-Giorgianni, D M Desiderio
Mar 10, 2001·Science·E Pennisi
Mar 20, 2001·The Journal of Clinical Investigation·B E HaywardD T Bonthron
May 3, 2002·Proteomics·Sarka Beranova-GiorgianniDominic M Desiderio
Feb 18, 2003·Endocrine Reviews·Charles V ClevengerLinda A Schuler
May 16, 2003·Proteomics·Xianquan Zhan, Dominic M Desiderio
Sep 23, 2003·Clinical Chemistry·Xianquan Zhan, Dominic M Desiderio
Mar 5, 2004·Proteomics·Francesco GiorgianniDominic M Desiderio
Mar 18, 2004·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Geert BaggermanLiliane Schoofs
Oct 21, 2004·Mass Spectrometry Reviews·Xianquan Zhan, Dominic M Desiderio
Feb 18, 2005·Proteomics·Xianquan ZhanDominic M Desiderio
Aug 16, 2005·Analytical Chemistry·Yingxin ZhaoSarka Beranova-Giorgianni
Jun 15, 2006·Expert Review of Proteomics·Lennard J DekkerTheo M Luider
Jun 30, 2006·Pituitary·Sarka Beranova-GiorgianniFrancesco Giorgianni
Sep 29, 2006·Expert Review of Anticancer Therapy·Adam M SonabendMaciej S Lesniak
Nov 3, 2006·Molecular and Cellular Endocrinology·George R BousfieldNaomi E Rance
Apr 5, 2007·Current Biology : CB·Mark Ptashne
Sep 28, 2007·Natural Product Reports·Gemma L HollidayMartin J Warren
Oct 9, 2008·The Journal of Clinical Endocrinology and Metabolism·Fernando Colbari AmaralMargaret Castro
Jan 7, 2009·Journal of Proteome Research·Maxie KohlerMario Thevis
Mar 17, 2009·Colloids and Surfaces. B, Biointerfaces·Yingchao LiuJianhong Zhu
Dec 24, 2009·Human Molecular Genetics·Anna Maria PorcelliGiuseppe Gasparre
Jan 9, 2010·Methods in Molecular Biology·Xianquan Zhan, Dominic M Desiderio
Feb 18, 2010·International Journal of Mass Spectrometry·Xianquan Zhan, Dominic M Desiderio
Apr 30, 2010·BMC Medical Genomics·Xianquan Zhan, Dominic M Desiderio
Jun 23, 2010·Learning & Memory·Ashok N Hegde
Nov 10, 2010·European Journal of Endocrinology·Diana Cruz-TopeteJohn J Kopchick

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Nature Microbiology
Cristina Vilanova, Manuel Porcar
The Journal of the American Academy of Psychiatry and the Law
Linda J Gottlieb
© 2021 Meta ULC. All rights reserved