The use of metronidazole and amoxicillin in the treatment of advanced periodontal disease. A prospective, controlled clinical trial

Journal of Clinical Periodontology
T BerglundhJ Lindhe

Abstract

The present clinical trial was performed to study the effect of systemic administration of metronidazole and amoxicillin as an adjunct to mechanical therapy in patients with advanced periodontal disease. 16 individuals, 10 female and 6 male, aged 35-58 years, with advanced periodontal disease were recruited. A baseline examination included assessment of clinical, radiographical, microbiological and histopathological characteristics of periodontal disease. The 16 patients were randomly distributed into 2 different samples of 8 subjects each. One sample of subjects received during the first 2 weeks of active periodontal therapy, antibiotics administered via the systemic route (metronidazole and amoxicillin). During the corresponding period, the 2nd sample of subjects received a placebo drug (placebo sample). In each of the 16 patients, 2 quadrants (1 in the maxilla and 1 in the mandible) were exposed to non-surgical subgingival scaling and root planing. The contralateral quadrants were left without subgingival instrumentation. Thus, 4 different treatment groups were formed; group 1: antibiotic therapy but no scaling, group 2: antibiotic therapy plus scaling, group 3: placebo therapy but no scaling, group 4: placebo therapy plus s...Continue Reading

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Citations

May 15, 2001·Journal of Clinical Periodontology·G SerinoJ Lindhe
Feb 16, 2002·Journal of Clinical Periodontology·Axel SpahrBernd Haller
Mar 16, 2002·Journal of Clinical Periodontology·Peter EickholzPetra Ratka-Krüger
Oct 23, 2002·Journal of Clinical Periodontology·M FeresS S Socransky
Jun 6, 2003·Journal of Clinical Periodontology·G A Van der Weijden, M F Timmerman
Dec 17, 2003·Computer Methods in Biomechanics and Biomedical Engineering·Igor Grabec, Dusan Groselj
Aug 23, 2008·Journal of Dental Research·J Cunha-CruzB Saver
Jun 18, 2010·The Journal of Oral Implantology·Gregory-George K ZafiropoulosOliver Hoffmann
Feb 20, 2004·Annals of Periodontology·Anne D HaffajeeJohn C Gunsolley
Jun 27, 2002·Journal of Periodontology·Rainer BuchmannDieter E Lange
Jan 7, 2005·Journal of Periodontology·Jørgen Slots, UNKNOWN Research, Science and Therapy Committee
Aug 7, 2009·Journal of Periodontology·Erica Del Peloso RibeiroMárcio Zaffalon Casati
Mar 11, 2010·Journal of Periodontology·Emine Cifcibasi YekAlpdogan Kantarci
Sep 2, 2014·Materials Science & Engineering. C, Materials for Biological Applications·Bryan R Orellana, David A Puleo
May 19, 2009·International Journal of Medical Microbiology : IJMM·Giuseppe ValenzaUlrich Vogel
Feb 5, 2005·Journal of Clinical Periodontology·Ene-Renate PähklaRein Pähkla
Sep 10, 2009·Australian Dental Journal·L J A Heitz-Mayfield
Aug 9, 2008·Australian Dental Journal·S C H Yeung

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