PMID: 11444340Jul 11, 2001Paper

The use of misoprostol for mid-trimester therapeutic termination of pregnancy

Tropical Doctor
J Munthali, J Moodley


Extra-amniotic prostaglandin F2alpha (PG F2alpha) is probably the most widely used medical method for mid-trimester termination of pregnancy. The method is highly effective but is financially costly, particularly for poor countries faced with restricted health budgets. The aim of this study was to establish whether misoprostol administered vaginally is as effective as PG F2alpha. Sixty-one patients were prospectively randomized to receive either misoprostol (n=30) vaginally, or PG F2alpha (n=31) extra-amniotically. The overall success rate was 83.6%. The success rates in the misoprostol and PG F2alpha groups were 83.3% and 83.8% respectively. There was no statistical difference in the groups in relation to side effects. In this carefully selected group of patients, misoprostol was as safe and effective as PG F2alpha in mid-trimester termination of pregnancy. In these days of financial constraints, misoprostol is the preferred method for mid-trimester termination of pregnancy.


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Oct 30, 2004·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·H Fletcher, A McCaw-Binns

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Jan 31, 2004·Obstetrical & Gynecological Survey·Yap-Seng ChongSabaratnam Arulkumaran
Jan 25, 2006·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·A NigamA Prakash
Jan 21, 2011·The Cochrane Database of Systematic Reviews·Hajo WildschutNathalie Kapp

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