The use of neuralgia medications to treat sensory neuropathic cough: our experience in a retrospective cohort of thirty-two patients

PeerJ
Zachary J Bastian, Robert W Bastian

Abstract

Objective. This study sought to: (1) quantify response rate and efficacy of amitriptyline, desipramine, and gabapentin in treating sensory neuropathic cough; and (2) describe an efficient treatment protocol. Study Design. This study is a retrospective case series. Methods. Persons diagnosed with sensory neuropathic cough during a one-year period were potential study candidates. To bolster the diagnosis credibility, only persons who had been treated elsewhere for gastroesophageal reflux disease, asthma, and allergy with no reduction of cough were included. Upon diagnosis of sensory neuropathic cough, each person was treated with either amitriptyline, desipramine, or gabapentin, titrating the dose upward to desired benefit or the dose limit. If the benefit was insufficient, another of the medications was used next, using a similar dose escalation strategy. Data points included patient demographics, initial and final medication, final dose, and degree of improvement. Results. 32 patients met the diagnostic and inclusion criteria and had a complete data set. 94% (30 of 32) of the patients responded to at least one of the medications. The 32 patients undertook a total of 45 single-medication trials. Patients reported symptom relief ...Continue Reading

References

May 18, 2005·The Annals of Otology, Rhinology, and Laryngology·Bryant Lee, Peak Woo
Jul 4, 2006·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Robert W BastianKathelijne G Delsupehe
Jun 26, 2009·The Laryngoscope·Stacey L HalumBryan R McRae
Apr 16, 2010·The Annals of Otology, Rhinology, and Laryngology·Byron K Norris, John M Schweinfurth
Nov 6, 2010·Journal of Voice : Official Journal of the Voice Foundation·Anne E Vertigan, Peter G Gibson
Apr 29, 2011·Expert Opinion on Pharmacotherapy·Peter G Gibson, Nicole M Ryan
Nov 2, 2012·Cough·Charlotte Van de KerkhoveLieven J Dupont
Jan 5, 2014·The Cochrane Database of Systematic Reviews·Michael P T LunnPhilip J Wiffen
Sep 24, 2014·The Cochrane Database of Systematic Reviews·Leslie HearnTudor Phillips
Dec 6, 2014·Pain Research & Management : the Journal of the Canadian Pain Society = Journal De La Société Canadienne Pour Le Traitement De La Douleur·Dwight MoulinUNKNOWN Canadian Pain Society
Jan 9, 2015·The Cochrane Database of Systematic Reviews·Sheena DerryR Andrew Moore

❮ Previous
Next ❯

Citations

May 26, 2016·The Laryngoscope·Marisa A Ryan, Seth M Cohen
Jun 22, 2018·Tuberculosis and Respiratory Diseases·Guanglin ShiHuan Zhao
Jul 18, 2018·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Andrew J BowenPaul C Bryson
Apr 11, 2018·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Andrew Jay BowenPaul C Bryson
Jan 31, 2018·Journal of Pain & Palliative Care Pharmacotherapy·Rab RazzakThomas J Smith
Nov 22, 2020·The Annals of Otology, Rhinology, and Laryngology·Sungjin A SongRamon A Franco
Mar 10, 2020·Gastrointestinal Endoscopy Clinics of North America·Caroline M BarrettMichael F Vaezi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergies & Environmental Factors

Environmental factors are strongly associated with the prevalence of allergies and are an increasing health concern worldwide. Discover the latest research on Allergies and Environmental Factors here.

Related Papers

Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
Robert W BastianKathelijne G Delsupehe
Acta paediatrica Scandinavica
S Conti NibaliG Magazzù
Zhonghua er ke za zhi. Chinese journal of pediatrics
Editorial Board of Chinese Journal of Pediatrics, Group of Gastroenterology, Chinese Pediatric Society, Chinese Medical Association
Chinese Medical Sciences Journal = Chung-kuo I Hsüeh K'o Hsüeh Tsa Chih
Zhong-gao Wang
© 2021 Meta ULC. All rights reserved