PMID: 9424345Jan 1, 1997Paper

The use of nifedipine for overcoming the insufficient preventive effect of lithium carbonate in patients with affective and schizoaffective psychoses

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova
L V SnedkovaG P Panteleeva

Abstract

26 patients with affective and schizoaffective psychoses either therapeutically resistant to lithium salts or with intolerance to them were treated. Control period of preventive therapy (lithium carbonate in average doses O.6-O.9 g daily) and experimental period (nifedipine, average doses 30-40 mg daily) were equal in duration, 2 years exactly. Preventive effect of nifedipine exceeded the same effect of lithium carbonate in 65.4% of patients. The total duration of affective attacks in the experimental period was reduced on 46.8% and their frequency-on 31.7% in comparison with the control period. A number of hospital admissions decreased (on 52.2%) with a simultaneous tendency to transition of a disease to a more light level (a number of attacks of cyclothymic level increased on 17.3%). The data gives ground for the perspectives of application of nifedipine in the cases of insufficient prophylactic effect or intolerance to lithium salts.

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved