PMID: 15227229Jan 1, 1989Paper

The use of nitroprusside to characterize aortic pressure-diameter relationships

Texas Heart Institute Journal
J J FergusonR G McKay

Abstract

The viscoelastic properties of the wall of the ascending aorta can be determined by calculating the relationship between pressure and diameter of the vessel. Because of potential nonlinearities in aortic pressure-diameter relationships, however, pressure-diameter curves are more accurate than compliance expressed as a single value in measuring aortic viscoelastic properties. To determine whether nitroprusside could be used to obtain aortic pressure-diameter curves over a wide range, we measured simultaneous aortic pressure and diameter in anesthetized dogs. The inferior vena cava (IVC) of each animal was briefly occluded to generate a baseline series of pressure-diameter points over a wide range of pressure and diameter. We found that moderate lowering of systolic arterial pressure (30 mmHg) with nitroprusside did not significantly affect the aortic pressure-diameter relationship in comparison with control measurements during brief IVC occlusions at similar pressures and diameters. Prolonged inferior vena caval occlusion and a more profound lowering of arterial pressure with nitroprusside or IVC occlusion resulted in a leftward and upward shift of the aortic pressure-diameter relationship, with higher pressures at comparable di...Continue Reading

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.