The Use of Noncontrast Quantitative MRI to Detect Gadolinium-Enhancing Multiple Sclerosis Brain Lesions: A Systematic Review and Meta-Analysis.

AJNR. American Journal of Neuroradiology
A GuptaY Wang

Abstract

Concerns have arisen about the long-term health effects of repeat gadolinium injections in patients with multiple sclerosis and the incomplete characterization of MS lesion pathophysiology that results from relying on enhancement characteristics alone. Our aim was to perform a systematic review and meta-analysis analyzing whether noncontrast MR imaging biomarkers can distinguish enhancing and nonenhancing brain MS lesions. Our sources were Ovid MEDLINE, Ovid Embase, and the Cochrane data base from inception to August 2016. We included 37 journal articles on 985 patients with MS who had MR imaging in which T1-weighted postcontrast sequences were compared with noncontrast sequences obtained during the same MR imaging examination by using ROI analysis of individual MS lesions. We performed random-effects meta-analyses comparing the standard mean difference of each MR imaging metric taken from enhancing-versus-nonenhancing lesions. DTI-based fractional anisotropy values are significantly different between enhancing and nonenhancing lesions (P = .02), with enhancing lesions showing decreased fractional anisotropy compared with nonenhancing lesions. Of the other most frequently studied MR imaging biomarkers (mean diffusivity, magneti...Continue Reading

References

Apr 1, 1991·Medical Decision Making : an International Journal of the Society for Medical Decision Making·D G Fryback, J R Thornbury
Oct 12, 2000·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·R BammerF Fazekas
Dec 12, 2002·Multiple Sclerosis : Clinical and Laboratory Research·F FazekasS Strasser-Fuchs
Nov 6, 2003·European Radiology·Nickolas PapanikolaouNicholas Gourtsoyiannis
Nov 12, 2005·Annals of Neurology·Chris H PolmanJerry S Wolinsky
Apr 20, 2007·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Joonmi OhDaniel Pelletier
Jun 26, 2007·European Journal of Radiology·Ismail YurtseverMufit Parlak
Feb 5, 2008·Brain : a Journal of Neurology·Machteld M VellingaFrederik Barkhof
Mar 11, 2009·Archives of Neurology·Paul S GiacominiDouglas L Arnold
Feb 11, 2010·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Ives R LevesqueG Bruce Pike
Mar 31, 2010·Multiple Sclerosis : Clinical and Laboratory Research·I J van den ElskampF Barkhof
Oct 16, 2010·AJNR. American Journal of Neuroradiology·R J FoxM D Phillips
May 13, 2011·Journal of Magnetic Resonance Imaging : JMRI·Irene M VavasourAlex L MacKay
Oct 23, 2012·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Y LiuS C Kolbe
Apr 5, 2013·Journal of Magnetic Resonance Imaging : JMRI·Alina JurcoaneElke Hattingen
Jun 14, 2013·Neurology·Vanessa WiggermannAlexander Rauscher
Oct 17, 2015·AJNR. American Journal of Neuroradiology·I BlystadE-M Larsson
Nov 26, 2015·NeuroImage. Clinical·Wendy S VargasSusan A Gauthier
Jan 27, 2016·Journal of the American College of Radiology : JACR·Ashkan A MalayeriDavid A Bluemke
Mar 19, 2016·PloS One·Tobias Djamsched FaizySusanne Siemonsen
Sep 30, 2016·Multiple Sclerosis : Clinical and Laboratory Research·Ludwig SchlemmMichael Scheel

❮ Previous
Next ❯

Citations

Dec 18, 2018·Recent Patents on Biotechnology·Feng LinYi Wang
Jan 25, 2020·Journal of Neurology, Neurosurgery, and Psychiatry·Luca ProsperiniClaudio Gasperini
Jun 3, 2020·Multiple Sclerosis : Clinical and Laboratory Research·Cristina Granziera, Daniel S Reich
Jul 10, 2020·RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin·Paul EichingerBenedikt Wiestler
Aug 6, 2019·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Pascal SpincemailleYi Wang
Dec 29, 2020·NeuroImage. Clinical·Po-Jui LuCristina Granziera
Feb 5, 2021·PloS One·Christian ThalerSusanne Gellißen
May 6, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Carl J J HerrmannThoralf Niendorf
Aug 9, 2021·Multiple Sclerosis and Related Disorders·Linford FernandesUNKNOWN UK MS Trials and Registries Consortium investigators

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.