The use of octreotide in the treatment of chylothorax following cardiothoracic surgery

Interactive Cardiovascular and Thoracic Surgery
Nur A IsmailJoel Dunning

Abstract

A best evidence topic in cardiothoracic surgery was written according to a structured protocol. The question addressed was 'Is octreotide (a long-acting somatostatin analogue) effective in patients with post-operative or traumatic chylothorax as a part of conservative management to reduce lymphorrhagia?' Altogether 180 papers were found using the reported search, of which 20 represented the best evidence to answer the clinical question. One case was reported twice and therefore was excluded, leaving us with 19 papers. The authors, journal, date and country of publication, patient group studied, study type, relevant outcomes and results of these papers are tabulated. Although rare, iatrogenic and traumatic chylothorax have been well described in the literature. At present, there have been no randomized controlled clinical trials on the use of octreotide in chylothorax. Sixteen of 19 papers found octreotide to be effective in the treatment of chylothorax. Octreotide was found to have no complementary effect in three reports. Two of the papers were retrospective studies: one a randomized controlled trial in canines, and the remainder were case reports and case series. The two retrospective studies showed a success rate of 87-90% i...Continue Reading

References

Jul 13, 2000·The Annals of Thoracic Surgery·R F Kelly, S J Shumway
Mar 13, 2001·Chest·N J DemosJ E Scerbo
Jun 18, 2002·Chest·Dimitrios MikroulisGeorgios Bougioukas
Sep 11, 2003·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Juan José MaféJosé M Rodríguez Paniagua
May 12, 2004·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Tomasz M ZiedalskiJohn L Faul
Aug 23, 2005·Asian Cardiovascular & Thoracic Annals·Abel A Gómez-CaroJosé L Martín de Nicolás
Jun 3, 2006·The Journal of Laryngology and Otology·S SrikumarT A B Westin
Mar 14, 2007·Annals of Vascular Surgery·Fabio BariliPaolo Biglioli
Aug 3, 2007·Interactive Cardiovascular and Thoracic Surgery·Joel DunningKevin Mackway-Jones

❮ Previous
Next ❯

Citations

Feb 6, 2017·Archivos de bronconeumología·Jorge GarcíaTomás Fernández de Sevilla
Oct 6, 2017·Oncotarget·Shulan LvQiling Li
Jan 11, 2019·Orphanet Journal of Rare Diseases·Jana PospiskovaPavel Zak
Jul 28, 2019·Medwave·Luis Alejandro Rodríguez-HidalgoDiana Cecilia Ruiz-Caballero
Jul 14, 2019·BMJ Case Reports·Yee-Shiuan Chen, Pauras Memon
Sep 6, 2018·Intractable & Rare Diseases Research·Manasvini BhattAshutosh Biswas
Feb 13, 2020·Journal of Magnetic Resonance Imaging : JMRI·Waleska M Pabon-RamosLynne M Koweek
Dec 19, 2019·BMJ Case Reports·Abdullah Al-AbchaHeather Laird-Fick
Apr 28, 2018·Journal of the American Veterinary Medical Association·Lucile ChassangElizabeth O'Toole
Sep 19, 2020·Surgery Today·Vaibhav Kumar VarshneyPushpinder Singh Khera
Jan 22, 2021·International Journal of Surgery Case Reports·Eleonora LovatiBeatrice Aramini
May 18, 2021·Interactive Cardiovascular and Thoracic Surgery·Sudharsan Madhavan, Masakazu Nakao

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.