The use of oral granisetron versus intravenous ondansetron for antiemetic prophylaxis in patients undergoing laparoscopic surgery: the effect on emetic symptoms and quality of recovery

Anesthesia and Analgesia
Paul F WhiteTed Khalili

Abstract

Based on comparative studies in patients receiving emetogenic chemotherapy, it has been suggested that granisetron would be more effective than ondansetron for the prevention of postdischarge nausea and vomiting (PDNV). However, there have been no direct comparisons of these two popular 5-HT3 antagonists with respect to PDNV and quality of recovery. We designed this randomized, double-blind study to compare the antiemetic efficacy of oral granisetron (1 mg) to a standard IV dose of ondansetron (4 mg) when administered for antiemetic prophylaxis as part of a multimodal regimen in a laparoscopic surgical population. A total of 220 patients undergoing laparoscopic surgery with a standardized general anesthetic technique were enrolled in this prospective study at two major medical centers. Patients were randomly assigned to one of two prophylactic treatment groups: the control (ondansetron) group received an oral placebo 1 h before surgery and ondansetron, 4 mg IV, at the end of the surgery, and the granisetron group received granisetron, 1 mg per os, 1 h before surgery, and normal saline, 2 mL IV, at the end of the surgery. The early recovery profiles, requirement for rescue antiemetics, incidence of PDNV, and the side effects wer...Continue Reading

References

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Citations

Apr 6, 2013·BMC Pharmacology & Toxicology·H K Ruben ThanacoodyD Nicholas Bateman
May 14, 2009·Therapeutics and Clinical Risk Management·Neil A Muchatuta, Michael J Paech
Nov 22, 2011·Journal of Perianesthesia Nursing : Official Journal of the American Society of PeriAnesthesia Nurses·Jan Odom-Forren
Dec 21, 2013·Anesthesia and Analgesia·Tong J GanUNKNOWN Society for Ambulatory Anesthesia
Jul 18, 2008·Anesthesia and Analgesia·Paul F WhiteUNKNOWN POST-OP Study Group
Sep 22, 2011·Current Opinion in Anaesthesiology·M Stephen MeltonTong J Gan
Apr 30, 2017·Journal of Anesthesia·Xuezhao CaoHong Ma
Oct 20, 2020·The Cochrane Database of Systematic Reviews·Stephanie WeibelPeter Kranke

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