The use of other drugs to allow a lower dosage of cyclosporin to be used. Therapeutic and pharmacoeconomic considerations

Clinical Pharmacokinetics
T E Jones

Abstract

Since its discovery in 1970, and introduction into clinical practice in 1978, cyclosporin has become the most important immunosuppressive drug used to prevent organ transplant rejection. This has been achieved by virtue of the improved graft survival rates and adverse effect profiles in patients when compared with that of the older agents. Cyclosporin is substantially more expensive (both to provide and to monitor) however, and the magnitude of these costs may preclude its use, particularly where the transplant recipient is required to pay. Cyclosporin has a complex pharmacokinetic profile with poor absorption, extensive metabolism to more than 30 metabolites and considerable inter- and intrapatient variability. Many transplant centres routinely use drugs ("cyclosporin-sparing agents') to allow a reduction in the dosage of cyclosporin while maintaining therapeutic blood cyclosporin concentrations. The use of a second drug to affect the pharmacokinetic profile of a primary drug is not new, but the use of cyclosporin-sparing agents is a departure from previous practices in that this coprescription is primarily for economic reasons. The decision to use these agents (and the choice of agent) is based upon economic and other factors...Continue Reading

Citations

Dec 24, 2005·European Journal of Clinical Pharmacology·Amr El-HusseiniMohamed Sobh
Nov 13, 2003·Transplantation Proceedings·J DominguezR Norambuena
Jul 15, 1998·British Journal of Clinical Pharmacology·H L McLeod
Aug 17, 2001·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·R SindhiJ F Dunne
Jul 9, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Amr El-HusseiniMohamed Sobh
Mar 19, 2005·Nephron. Clinical Practice·Amr El-HusseiniMohamed Sobh
Mar 10, 2000·Clinical Pharmacokinetics·K VenkatakrishnanD J Greenblatt
Aug 23, 2002·Clinical Pharmacokinetics·Uwe ChristiansAlfonso Lampen
Dec 18, 2013·Indian Journal of Nephrology·A IyengarM Bitzan
Jul 2, 2005·Expert Opinion on Emerging Drugs·T Jones
Oct 23, 1998·Journal of Drug Targeting·B A Klyashchitsky, A J Owen
Jul 10, 2003·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·L JinJ H Lin
Sep 1, 2014·Clinical Pharmacology in Drug Development·David J Greenblatt
Dec 14, 2004·The Annals of Pharmacotherapy·Raymond G Morris
Mar 7, 2017·Clinical Pharmacology in Drug Development·David J Greenblatt
Jun 13, 2017·International Journal of Molecular Sciences·Anna Gluba-BrzózkaJacek Rysz
Nov 18, 2003·British Journal of Clinical Pharmacology·Cyrus R KumanaTak Mao Chan
Aug 22, 2017·International Journal of Clinical Pharmacy·Julia AmkreutzAlbrecht Eisert
May 2, 2003·Journal of Clinical Pharmacology·Joseph C FleishakerNkechi E Azie
Sep 13, 2014·Journal of Clinical Pharmacology·H Karl Greenblatt, David J Greenblatt
Dec 9, 2009·Clinical and Experimental Immunology·G ZazaF P Schena
May 2, 2008·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Masakatsu KotsumaKenji Nishimura
Aug 26, 1998·Therapeutic Drug Monitoring·A J McLachlan, S E Tett
Nov 27, 2002·Therapeutic Drug Monitoring·Raymond G MorrisStephen Cook
Aug 5, 2000·The Annals of Pharmacotherapy·F A LoVecchio, H R Goltz

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