The use of personalized medicine for patient selection for renal transplantation: physicians' views on the clinical and ethical implications.

BMC Medical Ethics
Marianne Dion-LabrieHubert Doucet

Abstract

The overwhelming scarcity of organs within renal transplantation forces researchers and transplantation teams to seek new ways to increase efficacy. One of the possibilities is the use of personalized medicine, an approach based on quantifiable and scientific factors that determine the global immunological risk of rejection for each patient. Although this approach can improve the efficacy of transplantations, it also poses a number of ethical questions. The qualitative research involved 22 semi-structured interviews with nephrologists involved in renal transplantation, with the goal of determining the professionals' views about calculating the global immunological risk and the attendant ethical issues. The results demonstrate a general acceptance of this approach amongst the participants in the study. Knowledge of each patient's immunological risk could improve treatment and the post-graft follow-up. On the other hand, the possibility that patients might be excluded from transplantation poses a significant ethical issue. This approach is not seen as something entirely new, given the fact that medicine is increasingly scientific and evidence-based. Although renal transplantation incorporates scientific data, these physicians bel...Continue Reading

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Jan 19, 2013·Pharmacogenomics·Simon de DenusBarbara Vadnais
Oct 22, 2015·BMC Medical Ethics·Ramón Fuentes FernándezEduardo Borie
Mar 9, 2017·Canadian Journal of Kidney Health and Disease·Mirela MaierRuth Sapir-Pichhadze
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Apr 2, 2020·Canadian Journal of Kidney Health and Disease·Timothy CaulfieldPaul Keown
Nov 23, 2019·Pharmacogenomics·Kimberly M DeiningerChristina L Aquilante

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