The use of pharmacological-challenge fMRI in pre-clinical research: application to the 5-HT system.

Journal of Visualized Experiments : JoVE
A KlompL Reneman

Abstract

Pharmacological MRI (phMRI) is a new and promising method to study the effects of substances on brain function that can ultimately be used to unravel underlying neurobiological mechanisms behind drug action and neurotransmitter-related disorders, such as depression and ADHD. Like most of the imaging methods (PET, SPECT, CT) it represents a progress in the investigation of brain disorders and the related function of neurotransmitter pathways in a non-invasive way with respect of the overall neuronal connectivity. Moreover it also provides the ideal tool for translation to clinical investigations. MRI, while still behind in molecular imaging strategies compared to PET and SPECT, has the great advantage to have a high spatial resolution and no need for the injection of a contrast-agent or radio-labeled molecules, thereby avoiding the repetitive exposure to ionizing radiations. Functional MRI (fMRI) is extensively used in research and clinical setting, where it is generally combined with a psycho-motor task. phMRI is an adaptation of fMRI enabling the investigation of a specific neurotransmitter system, such as serotonin (5-HT), under physiological or pathological conditions following activation via administration of a specific cha...Continue Reading

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Citations

Mar 29, 2014·PloS One·Christian ScharingerLukas Pezawas
Nov 6, 2015·Frontiers in Pharmacology·Elisabeth JonckersAnnemie Van der Linden
Feb 11, 2020·Frontiers in Neuroinformatics·Francesca MandinoJoanes Grandjean

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Methods Mentioned

BETA
dissecting
dissection

Software Mentioned

FLIRT
McFlirt FMRIB Linear Image Registration Tool
ImageJ
FSL
FEAT
MCFLIRT
FMRIB
Stimulate
Analyze7
FEAT ( FMRI Expert Analysis Tool

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