PMID: 9556122Apr 29, 1998Paper

The use of phentolamine in the prevention of dopamine-induced tissue extravasation

Journal of Critical Care
D BeyE Valderrama

Abstract

The purpose of this study was to determine whether dopamine-induced tissue extravasation injury could be prevented with phentolamine. This was a prospective, randomized, blinded, and controlled animal study. Forty rats were evaluated to document the effects of dopamine compared with normal saline on tissue integrity, whether any tissue damage was concentration or volume dependent, and to determine the minimum concentration of dopamine resulting in tissue injury. Dopamine concentrations of 0.8 mg/mL and 3.2 mg/mL were tested. In a second part of this study, an additional 40 rats were evaluated to assess the efficacy of two different doses of phentolamine (0.5 mg and 1 mg) or normal saline, when injected within 10 minutes of dopamine administration to prevent or reverse tissue extravasation. Extravasation sites were evaluated clinically and histologically at 2, 4, 6, and 8 hours and were compared with a baseline sample. Outcome measures were as follows: (1) prebiopsy was ectodermal erythema, induration, and blanching; (2) postbiopsy was bubbling, darkening, pallor, and hematoma of the muscle fascia. Histology included neutrophil migration, mast cell degranulation, edema, and hemorrhage. Fisher's Exact Test with the Bonferroni met...Continue Reading

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Citations

Apr 10, 2014·The Annals of Pharmacotherapy·Ann Le, Samit Patel
Jun 25, 2008·Journal of Dental Research·M LaviolaJ A Yagiela
Feb 25, 2005·Anesthesia and Analgesia·Wolfram SchummerWaheedullah Karzai
Sep 6, 2001·Journal of Perinatology : Official Journal of the California Perinatal Association·M SubhaniJ D DeCristofaro
Dec 1, 2012·Inflammopharmacology·Ghada M SuddekNariman M Gameil
Mar 4, 2014·Journal of Infusion Nursing : the Official Publication of the Infusion Nurses Society·John M Allen

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