The use of plasmapheresis for rapid hormonal control in severe hyperthyroidism caused by a partial molar pregnancy

Archives of Gynecology and Obstetrics
Ertan AdaliNedim Turan

Abstract

The hormone human chorionic gonadotropin (hCG), secreted by molar tissue, is structurally similar to thyroid-stimulating hormone (TSH). Hyperthyroidism in trophoblastic disease is thought to be the result of TSH receptor activation by extremely elevated levels of hCG. Significant elevations in hCG levels are less common in cases of partial moles. We describe a patient with partial molar pregnancy in which the levels of hCG and thyroid hormones were significantly high. It was not possible to decrease the elevated thyroid hormone concentrations to safer levels using medical treatment strategies only. Since the patient's vaginal bleeding increased gradually, plasmapheresis was used to rapidly control the thyroid hormones during the preoperative preparation of the patient for anesthesia and surgery. After the evacuation of the molar tissue, the levels of the thyroid hormones detected after the plasmapheresis started to decrease even further. Plasmapheresis may be used as an alternative to antithyroid medication for the rapid control of thyroid hormones in cases of severe hyperthyroidism caused by molar pregnancy.

References

May 1, 1976·Anesthesiology·J M KimV McCann
Aug 13, 1998·Archives of Pediatrics & Adolescent Medicine·J C Sanchez, J E Sanchez
May 23, 2002·The American Journal of the Medical Sciences·Kanakasabai L NarasimhanEdward B Ruby
Jun 13, 2003·Endocrinology and Metabolism Clinics of North America·Roy W Langley, Henry B Burch
Aug 18, 2004·International Journal of Clinical Practice·N OzbeyS Molvalilar
Feb 17, 2007·Clinical Obstetrics and Gynecology·Elizabeth I O GarnerRoss S Berkowitz
Mar 21, 2008·Thyroid : Official Journal of the American Thyroid Association·Niyati U ChiniwalaKelli Yacono

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Citations

Dec 5, 2009·The Journal of Emergency Medicine·Joshua B Moskovitz, Michael C Bond
Dec 2, 2015·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Piero MarsonGiustina De Silvestro
Nov 24, 2011·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Clotilde MullerFrancois Chantrel
Jun 23, 2010·Journal of Clinical Apheresis·Zbigniew M SzczepiorkowskiUNKNOWN Apheresis Applications Committee of the American Society for Apheresis
Feb 7, 2013·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·B Ekiz BilirS Hekimoğlu
Sep 17, 2011·Revista brasileira de anestesiologia·Carlos Eduardo David de AlmeidaDenise Fernandes Vieira
Jun 21, 2016·Journal of Clinical Apheresis
Jan 16, 2021·Thyroid Research·Jarett Vanz-Brian Pereira, Taylor Lim
Mar 5, 2021·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Tugce Apaydin, Dilek Gogas Yavuz

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