The use of Platelet-rich Fibrin in the management of medication-related osteonecrosis of the jaw: A case series

Journal of Stomatology, Oral and Maxillofacial Surgery
C Fernando de Almeida Barros MourãoG Gomes Alves

Abstract

Medication related osteonecrosis of the jaw (MRONJ) is characterized by exposed necrotic bone in the maxillofacial region that persists for more than eight weeks in patients taking antiresorptive or antiangiogenic drugs for bone metastasis or osteoporosis. The management of such condition depends on several factors, among which the staging of MRONJ. Though, a specific gold standard treatment has not been established to date. The aim of this case series is to describe the outcome of surgical treatment of MRONJ with the adjunct of Platelet-rich Fibrin (PRF). Eleven patients under therapy with alendronate underwent surgical removal of necrotic bone and debridement, followed by placement of PRF membranes in the bone defect. The outcome of the surgical treatment was successful in all patients, in a follow-up range from 12 to 36 months. In the cases presented, the macroscopic evaluation showed excellent and fast soft tissue healing, with no recurrence of bone exposure and no signs of infections. PRF membranes were also effective for postsurgical pain control. The use of PRF may represent a valuable adjunct in the surgical management of MRONJ.

Citations

Dec 25, 2019·British Dental Journal·Richard MooreStephen Henderson
Jul 30, 2020·São Paulo Medical Journal = Revista Paulista De Medicina·Aloizio Premoli MacielPaulo Sérgio da Silva Santos
Sep 26, 2019·Frontiers in Cardiovascular Medicine·Faez Saleh Al-HamedFaleh Tamimi
Jul 1, 2020·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Jiri ZelinkaOliver Bulik
Jun 17, 2020·Journal of Stomatology, Oral and Maxillofacial Surgery·C BoulandP Philippart
Dec 8, 2020·Morphologie : Bulletin De L'Association Des Anatomistes·J-D Kün-Darbois, F Fauvel
Apr 30, 2021·Journal of the Korean Association of Oral and Maxillofacial Surgeons·Gianfilippo NifosìAntonio Fabrizio Nifosì
Jun 8, 2021·BioMed Research International·Michele MirandaPatrizio Bollero
Aug 28, 2021·International Journal of Environmental Research and Public Health·Olga Di FedeAntonio Galvano
Oct 26, 2020·Journal of Stomatology, Oral and Maxillofacial Surgery·T PourlakM Yousefi

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