The use of plerixafor in hematopoietic progenitor cell collection in pediatric patients: a single center experience.

Cytotherapy
Huy P PhamJoseph Schwartz

Abstract

Plerixafor was recently approved for use in combination with granulocyte-colony-stimulating factor (G-CSF) for hematopoietic progenitor cell (HPC) collection by apheresis in adults with multiple myeloma (MM) or non-Hodgkin lymphoma (NHL). However, its efficacy in pediatric patients is not well-studied; thus, we report on our institutional experience with this population. A retrospective observational analysis was performed using both stem cell-processing laboratory information as well as apheresis charts and medical records on all pediatric patients who received plerixafor as part of the mobilization regimen between December 2006 and December 2010. The primary outcome was collection yield. Secondary outcomes included the ability to undergo autologous hematopoietic stem cell transplantation (auto-HSCT) and engraftment status. Eighteen HPC collections by apheresis representing seven mobilization courses were performed on five pediatric patients with poor mobilization status (three males, two females; median age 14 years). Median pre-harvest peripheral blood CD34(+) cell (PB CD34(+)) count was 6.88/μL. A strong correlation between pre-harvest PB CD34(+) count and collection yield was observed. Median total collection yield was 2.2...Continue Reading

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Citations

Nov 12, 2015·Pediatric Cardiology·Eric J KortStefan Jovinge

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