The use of prostate specific antigen density to predict clinically significant prostate cancer.

Scientific Reports
Igor YusimNicola J Mabjeesh

Abstract

The purpose of this study was to assess the predictive value of prostate specific antigen density (PSAD) for detection of clinically significant prostate cancer in men undergoing systematic transrectal ultrasound (TRUS)-guided prostate biopsy. We retrospectively analyzed data of men who underwent TRUS-guided prostate biopsy because of elevated PSA (≤ 20 ng/ml) or abnormal digital rectal examination. Receiver operating characteristic curve analysis to compare PSA and PSAD performance and chi-square automatic interaction detector methodologies were used to identify predictors of clinically significant cancer (Gleason score ≥ 7 or international society of urological pathology grade group ≥ 2). Nine-hundred and ninety-two consecutive men with a median age of 66 years (IQR 61-71) were included in the study. Median PSAD was 0.10 ng/ml2 (IQR 0.10-0.22). Prostate adenocarcinoma was diagnosed in 338 men (34%). Clinically significant prostate adenocarcinoma was diagnosed in 167 patients (50% of all cancers and 17% of the whole cohort). The AUC to predict clinically significant prostate cancer was 0.64 for PSA and 0.78 for PSAD (P < 0.001). The highest Youden's index for PSAD was at 0.20 ng/ml2 with 70% sensitivity and 79% specificity for...Continue Reading

References

Mar 1, 1988·The Keio Journal of Medicine·C B Brendler
Feb 19, 2005·Annals of Oncology : Official Journal of the European Society for Medical Oncology·P Boyle, J Ferlay
May 5, 2010·International Journal of Urology : Official Journal of the Japanese Urological Association·Koichi OkadaTsuneharu Miki
Jan 21, 2014·European Urology·Stacy LoebRuth Etzioni
May 20, 2015·European Urology·Scott A TomlinsArul M Chinnaiyan
Dec 21, 2017·Prostate Cancer and Prostatic Diseases·Tobias NordströmMartin Eklund

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Citations

Jul 3, 2021·International Journal of Molecular Sciences·Belén Pastor-NavarroJosé Antonio López-Guerrero
Aug 7, 2021·Journal of Personalized Medicine·James MeehanArran K Turnbull

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Methods Mentioned

BETA
biopsies
biopsy

Software Mentioned

SPSS Statistics
CHAID
SelectMDx

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