The use of proton pump inhibitors in an Italian hospital: focus on oncologic and critical non-ICU patients

International Journal of Clinical Pharmacy
Maria MeliNatale D'Alessandro

Abstract

Proton pump inhibitors (PPIs) are among the most misused drugs both at the community and hospital level. Recently, possible risks have been underscored, suggesting the importance of limiting PPI use to proven indications. To survey the appropriateness of PPI use in a University hospital in Italy. Setting Azienda Ospedaliera Universitaria Policlinico 'P. Giaccone', in Palermo, Italy. A one day-observational study, reviewing patients' medical records to identify treatments with PPIs and the indications for their use. After discharge, a subgroup of the cohort was followed up to assess the continuation of therapy at home. Appropriateness was evaluated according to the indications stated in the official product information sheet and supported by the AIFA notes. Prevalence and appropriateness of PPI use in the hospital and after discharge. In the index day 62.9 % of 343 evaluable patients received a PPI. In only 29.1 % of these, the treatment could be considered appropriate. The most frequent reasons for inappropriate treatment were stress ulcer prophylaxis in low risk patients and unwarranted gastro-protection in drug treated patients. 30.9 % of patients received PPIs for uncertain indications: of these, 25.7 % were "critical" patie...Continue Reading

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Citations

Dec 7, 2017·Gastroenterology Nursing : the Official Journal of the Society of Gastroenterology Nurses and Associates·Seyed Masoom MasoompourHamideh Mahdaviazad
May 8, 2019·International Journal of Environmental Research and Public Health·Benjamin Ka Seng ThongKok-Yong Chin
Apr 1, 2017·Clinical Drug Investigation·Leon Fisher, Alexander Fisher
Oct 6, 2020·Frontiers in Pharmacology·Mária MatuzGyöngyvér Soós

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