PMID: 6161757Feb 1, 1981Paper

The use of quantitative sterile brush culture and gram stain analysis in the diagnosis of lower respiratory tract infection

Chest
R B TeagueR J Awe

Abstract

We prospectively evaluated 55 patients (58 studies) who presented for diagnostic fiberoptic bronchoscopy for the presence of lower respiratory tract infection. A sheathed, nonplugged, sterile brush passed transbronchoscopically under fluoroscopic control was used to retrieve bronchial secretions. These were evaluated using Gram stains, Wright-Giemsa stains, and quantitative bacterial cultures. In 18 studies of patients with known or suspected infection, polymorphonuclear leukocytes and bacterial were easily identifiable on Gram stain, and potential lower respiratory pathogens were recovered in concentrations greater than or equal to 10(6) colony-forming units (cfu)/ml. In 15 control studies of patients with noninfectious lung disease and in 17 studies of patients with suspected lung infection (nine with prior antibiotic therapy), organisms were not seen on Gram stain and in 28/32 studies bacteria were present in concentrations of less than or equal to 10(4) cfu/ml. The remaining eight studies were in patients proved to have active granulomatous disease. These studies establish the ability of a fiberoptic bronchoscopic technique to diagnose bacterial infection in a group of patients presenting difficult diagnostic problems.

References

Jan 12, 1976·JAMA : the Journal of the American Medical Association·M DavidsonD L Palmer
Jul 1, 1977·Journal of Clinical Microbiology·W L Drew
Aug 25, 1975·JAMA : the Journal of the American Medical Association·S B ThorsteinssonT Fagan
Jul 1, 1979·Chest·N WimberleyJ G Bartlett
Oct 1, 1977·British Journal of Diseases of the Chest·I T GardinerJ H Darrell
Jun 1, 1970·The Journal of Infectious Diseases·R M Schmidt, H S Rosenkranz
Sep 1, 1974·The American Review of Respiratory Disease·W M Murphy, R A Komorowski
Jan 1, 1973·Respiration; International Review of Thoracic Diseases·A WannerM A Sackner
Jan 1, 1968·Annals of Surgery·A J Okinaka, P Dineen
Feb 1, 1970·Annals of Internal Medicine·H H Hahn, H N Beaty

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Citations

Oct 1, 1996·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·A H MertensD Coolen
Apr 1, 1985·European Journal of Clinical Microbiology·R H Winterbauer
Mar 1, 1991·Diagnostic Microbiology and Infectious Disease·R C BartlettT Lerer
Sep 1, 1987·The American Review of Respiratory Disease·D G LorchS A Sahn
Aug 1, 1991·The American Review of Respiratory Disease·B W RamseyK Harris
Oct 1, 1994·Clinical Microbiology Reviews·V S Baselski, R G Wunderink
May 1, 1990·Journal of Veterinary Internal Medicine·P A PadridC E Cross
May 18, 2000·Chest·M S Niederman
Jun 1, 1985·Australian and New Zealand Journal of Medicine·A R GlanvilleR Bradbury
Oct 12, 1999·Clinics in Chest Medicine·S J Skerrett
Dec 1, 1991·Chest·U B Prakash, S E Stubbs
Dec 10, 1991·Journal of Intensive Care Medicine·K Gleeson, H Y Reynolds

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