The use of rabbits in male reproductive toxicology

Environmental Health Perspectives
D Morton

Abstract

The rabbit is the smallest and least expensive laboratory animal in which serial semen samples can be obtained for morphologic, biochemical, and fertility evaluation. The female rabbit has a predictable reproductive cycle and can be artificially inseminated with a known amount of sperm during fertility testing. These advantages make the rabbit an extremely valuable model for studying the effects of chemicals or other stimuli on the male reproductive system. Quantitative evaluation of the testis, semen, and accessory reproductive organs is important in order to detect subtle effects of a chemical on reproductive capacity. Evaluation of testis size, serum hormone concentrations, and the number, morphology, motility, and fertility of sperm in the ejaculate can be performed serially in the live rabbit. Weights of testes and accessory reproductive organs, estimates of daily sperm production, and histomorphometric data on the seminiferous epithelium can be obtained after sacrifice. Multinucleated spermatids, focal tubular hypospermatogenesis, swelling of spermatocytes, and cytoplasmic vacuoles in Sertoli's cells occur commonly in testes of control rabbits. These changes may be confused with toxic lesions. The incidence of multinuclea...Continue Reading

References

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Citations

Oct 9, 1998·Occupational and Environmental Medicine·P ApostoliM Vanhoorne
Dec 2, 2000·Reproductive Toxicology·R H Foote, E W Carney
Nov 14, 2003·Reproductive Toxicology·Petros YpsilantisConstantinos Simopoulos
May 4, 2011·Cell and Tissue Research·Yingjie WuYinghe Qin
Mar 16, 2013·Acta histochemica·Rosa María Vigueras-VillaseñorJulio César Rojas-Castañeda
Jul 25, 2009·Animal Reproduction Science·G BrecchiaC Castellini
Oct 23, 2016·Toxicologic Pathology·Akihisa KangawaMasatoshi Shibata
Sep 1, 1994·Veterinary Pathology·S R FrameJ W Green
Dec 29, 2000·Toxicologic Pathology·S Rehm
Nov 6, 2013·International Journal of Toxicology·Monice M FiumeF Alan Andersen
Apr 24, 2020·Toxicologic Pathology·Yoshinori YamagiwaHiroshi Satoh
Oct 23, 2014·American Journal of Physiology. Endocrinology and Metabolism·Daniel H MorganXuesong Chen
Oct 25, 2017·Birth Defects Research·Catherine A PicutD Stanislaus
Jul 2, 2021·Acta histochemica·Alan Jair Contreras-OrtizMaría Elena Trujillo-Ortega

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